| Vigabatrin for refractory complex partial seizures: multicenter single-blind study with long-term follow-up. | |
| | |
MedLine Citation:
|
PMID: 3808298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The irreversible GABA transaminase inhibitor vigabatrin (VGB) was given in a single-blind fashion to 89 patients with complex partial seizures (CPS) refractory to conventional drugs. The median number of CPS per month decreased from 11.0 to 5.0 after addition of VGB, and 51% of patients had a 50% or greater decrease in CPS frequency (p less than 0.001). Side effects (principally drowsiness, ataxia, and headache) occurred mainly during the initiation of therapy and decreased during therapy. After 12 weeks on VGB, side effects significantly interfered with functioning in only 13% of patients, and the efficacy:toxicity ratio warranted continued administration in 74% of patients. Coadministration of VGB resulted in a mean decrease of 20% in phenytoin serum concentration (p less than 0.001). Sixty-six patients with a favorable response to VGB during the single-blind study have been followed for a median of 16.7 months on VGB. No serious systemic or neurologic toxicity has been detected, and most patients have retained their initial favorable CPS control. |
| | |
Authors:
|
T R Browne; R H Mattson; J K Penry; D B Smith; D M Treiman; B J Wilder; E Ben-Menachem; M J Napoliello; K M Sherry; G K Szabo |
Related Documents
:
|
1963498 - The relationship between response to fluoxetine, plasma drug levels, imipramine binding... 15907758 - "seizure-alert dogs": observations from an inpatient video/eeg unit. 8795128 - An audit of the new antiepileptic drugs in clinical neurological practice. 7007988 - Is the therapy with carbamazepine more effective when measuring blood levels? 7445538 - The significance of electron dense deposits in mild lupus nephritis. 807098 - Bone marrow histology in monoclonal macroglobulinemia. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neurology Volume: 37 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1987 Feb |
Date Detail:
|
Created Date: 1987-03-10 Completed Date: 1987-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 184-9 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aminocaproic Acids
/
adverse effects,
metabolism,
therapeutic use* Anticonvulsants / adverse effects, metabolism, therapeutic use* Drug Interactions Epilepsy, Temporal Lobe / drug therapy* Follow-Up Studies Humans Vigabatrin |
| Chemical | |
Reg. No./Substance:
|
0/Aminocaproic Acids; 0/Anticonvulsants; 60643-86-9/Vigabatrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Early diagnosis of herpes simplex encephalitis by MRI.
Next Document: Lorazepam in childhood status epilepticus and serial seizures: effectiveness and tachyphylaxis.