| Vigabatrin reduces epileptiform activity in brain slices from pharmacoresistant epilepsy patients. | |
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MedLine Citation:
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PMID: 10924922 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human neocortical temporal lobe tissue resected for treatment of pharmacoresistant epilepsy was investigated. In slices prepared from this tissue, epileptiform field potentials (EFP) were induced by omission of magnesium from the artificial cerebrospinal fluid (ACSF). The effects of the gamma-aminobutyric acid transaminase inhibitor vigabatrin on EFP were tested. Vigabatrin exerted a dose-dependent reduction of the repetition rate of EFP: after 3 h of administration of vigabatrin in concentrations of 100 and 200 micromol/l, the repetition rate of EFP was reduced to 35% and 18% of the initial values, respectively. This effect was not reversible. In control experiments with neocortical slices from rats, vigabatrin reduced EFP in a comparable range. The results demonstrate a strong antiepileptic effect of vigabatrin on EFP in tissues from pharmacoresistant epilepsy patients. |
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Authors:
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U Musshoff; R Köhling; A Lücke; E Speckmann; I Tuxhorn; P Wolf; H W Pauuek; F Oppel |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 401 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-10-12 Completed Date: 2000-10-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 167-72 Citation Subset: IM |
Affiliation:
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Institut für Physiologie, Universität Münster, Robert-Koch-Str. 27a 48149, Münster, Germany. mushoff@uni-muenster.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Animals Anticonvulsants / pharmacology* Brain / drug effects*, physiopathology Dose-Response Relationship, Drug Drug Resistance Electrophysiology Epilepsy / physiopathology, prevention & control* Epilepsy, Temporal Lobe / physiopathology, prevention & control Female Humans Male Middle Aged Neostriatum / drug effects, physiopathology Rats Vigabatrin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 60643-86-9/Vigabatrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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