Document Detail


Vigabatrin and mental retardation in tuberous sclerosis: infantile spasms versus focal seizures.
MedLine Citation:
PMID:  22752486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tuberous sclerosis complex is a genetic disorder resulting in epilepsy and mental retardation. Vigabatrin has shown efficacy in the treatment of infantile spasms caused by tuberous sclerosis complex, but its effects on focal seizures caused by tuberous sclerosis complex have not been determined. We compared the efficacy of vigabatrin in patients with tuberous sclerosis complex-induced focal seizures and infantile spasms and assessed the mental outcomes in both groups. We retrospectively evaluated 31 children with tuberous sclerosis complex and epilepsy, who were treated with vigabatrin in a single tertiary center in Seoul, Korea. Vigabatrin treatment resulted in spasms cessation in 16 of 18 (88.9%) patients with infantile spasms, whereas 6 of 13 (46.2%) patients with focal seizures became seizure free. Initial response to vigabatrin had no effect on intellectual disability. Vigabatrin was highly effective in eliminating infantile spasms caused by tuberous sclerosis complex but was less effective in patients with focal seizures.
Authors:
Mi-Sun Yum; Eun Hye Lee; Tae-Sung Ko
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-06-29
Journal Detail:
Title:  Journal of child neurology     Volume:  28     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-12     Completed Date:  2013-07-26     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  308-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anticonvulsants / therapeutic use*
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Intellectual Disability / drug therapy*,  etiology
Male
Retrospective Studies
Seizures / drug therapy*,  etiology
Spasms, Infantile / drug therapy*,  etiology
Treatment Outcome
Tuberous Sclerosis / complications*
Vigabatrin / therapeutic use*
Grant Support
ID/Acronym/Agency:
R13 NS040925/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Anticonvulsants; GR120KRT6K/Vigabatrin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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