| Viewpoint: therapeutic implications of CTLA-4 compartmentalization. | |
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MedLine Citation:
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PMID: 12859525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding the regulatory events involved in the activation and inactivation of T cells is crucial to develop therapeutic approaches for autoimmune diseases and for organ transplantation. Co-stimulatory signals delivered through the CD28 receptor and inhibitory signals through CTLA-4 are required for the proper modulation of T cell responses and the induction and maintenance of peripheral tolerance. Manipulation of these signals is emerging as a potential strategy to prevent allograft rejection in different animal models. Recent data on the compartmentalization and the structural features of CTLA-4 within T cells provides critical information not only on the molecular basis of T cell inactivation by CTLA-4, but also on the key requirements for the successful development of therapeutic strategies targeting this molecule. |
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Authors:
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Miren L Baroja; Joaquín Madrenas |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Volume: 3 ISSN: 1600-6135 ISO Abbreviation: Am. J. Transplant. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-15 Completed Date: 2004-04-22 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 100968638 Medline TA: Am J Transplant Country: Denmark |
Other Details:
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Languages: eng Pagination: 919-26 Citation Subset: IM |
Affiliation:
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The John P. Robarts Research Institute, Department of Microbiology, The University of Western Ontario, London, Ontario, Canada N6A 5K8. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD Antigens, Differentiation / chemistry, immunology*, metabolism Cell Compartmentation* Humans Signal Transduction T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation; 0/cytotoxic T-lymphocyte antigen 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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