| Viewpoint: professional integrity in industry-sponsored clinical trials. | |
| | |
MedLine Citation:
|
PMID: 16186605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Evidence-based medicine (EBM) relies on accurate data derived from well-designed, clinically relevant randomized controlled trials (RCTs). Most randomized trials, however, are conducted by industry sponsors aiming at licensing and marketing drugs, which may weaken the usefulness of the findings to EBM. Disturbing evidence has emerged of widespread biases in industry-sponsored trials, including publication bias, selective reporting of findings, and distorted interpretation of results. These practices compromise the professional integrity of physician-investigators who contribute to them. In turn, the well-being of patients participating in RCTs may be jeopardized, and the evidence base upon which EBM is practiced may be corrupted. Regulatory reform alone will be inadequate to resolve these problems; attention must also be paid to physicians' professionalism. The authors recommend a change in the culture of academic medicine whereby physician-investigators who maintain professional integrity are rewarded or recognized. Educational interventions promoting integrity in clinical research may be one part of affecting such change. |
| | |
Authors:
|
Franklin G Miller; Howard Brody |
Related Documents
:
|
22545335 - Evidence-based medicine at the point of care: student utilization and faculty implicati... 19962575 - Albumin usage in clinical medicine: tradition or therapeutic? 11724485 - Assessment of best management practices for improvement of dissolved oxygen in chesapea... 21049305 - From evidence based medicine to mechanism based medicine. reviewing the role of pharmac... 22387655 - Contributions of ancient indian physicians - implications for modern times. 10316435 - Time management. getting more with less. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Academic medicine : journal of the Association of American Medical Colleges Volume: 80 ISSN: 1040-2446 ISO Abbreviation: Acad Med Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2005-09-27 Completed Date: 2005-12-13 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8904605 Medline TA: Acad Med Country: United States |
Other Details:
|
Languages: eng Pagination: 899-904 Citation Subset: AIM; E; IM |
Affiliation:
|
Unit on Clinical Research, Department of Clinical Bioethics, National Institutes of Health, Building 10, Room 1C118, Bethesda, Maryland 20892, USA. fmiller@nih.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Advertising as Topic Biomedical Research Clinical Trials as Topic* Evidence-Based Medicine Health Care Sector* Humans Physician's Role Professional Competence* Publication Bias |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Viewpoint: today's professionalism: engaging the mind but not the heart.
Next Document: Viewpoint: who's watching out for the clinical academician?