Document Detail

Video-assisted thoracic surgery lobectomy for non-small cell lung cancer in patients with a Charlson comorbidity index score of two or more.
MedLine Citation:
PMID:  19875973     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: We evaluated the feasibility and safety of the video-assisted thoracic surgery (VATS) lobectomy for non-small cell lung cancer (NSCLC) in patients with comorbidity. METHODS: Between April 2000 and December 2006, a prospective database of 58 consecutive patients undergoing a VATS lobectomy for NSCLC, who had a Charlson comorbidity index score of 2 or more, was retrospectively analyzed. The demographic, perioperative, histopathologic, and outcome variables, including the recurrence and survival, were assessed. RESULTS: The VATS lobectomy was successfully performed in 57 patients (16 women and 41 men; median age, 70 years). Twenty-three patients (40.4%) were aged 75 years or older. The total score of the Charlson comorbidity index was as follows: 2 in 26 patients, 3 in 13 patients, 4 in 12 patients, 5 in five patients, and 6 in one patient. None of the patients required a blood transfusion during surgery or during the postoperative course. We observed no intraoperative or in-hospital deaths, and no complications occurred in the 45 patients (78.9%). At a median follow-up of 34 months, a recurrence was observed in five patients who had advanced stages: a local recurrence in one and a distant recurrence in four. The overall 5-year survival rates for postoperative stage IA (n = 25) and IB (n = 16) were 100% and 94%, respectively. CONCLUSIONS: We believe that a VATS lobectomy is a feasible and safe procedure for NSCLC in patients with comorbidity because this modality demonstrates an acceptable morbidity and a favorable oncologic outcome.
Ryoichi Nakanishi; Toshihiro Yamashita; Soichi Oka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer     Volume:  5     ISSN:  1556-1380     ISO Abbreviation:  J Thorac Oncol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-25     Completed Date:  2010-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101274235     Medline TA:  J Thorac Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  56-61     Citation Subset:  IM    
Department of Thoracic Surgery, Shin-Kokura Hospital, Federation of National Public Service Personnel Mutual Aid Associations, Kokurakita-ku, Kitakyushu, Japan.
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MeSH Terms
Adenocarcinoma / secondary,  surgery*
Adenocarcinoma, Bronchiolo-Alveolar / secondary,  surgery*
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung / secondary,  surgery*
Carcinoma, Squamous Cell / secondary,  surgery*
Feasibility Studies
Follow-Up Studies
Lung Neoplasms / pathology,  surgery*
Middle Aged
Neoplasm Staging
Prospective Studies
Retrospective Studies
Survival Rate
Thoracic Surgery, Video-Assisted / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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