Document Detail

Vibrio cholerae hemolysin is apoptogenic to peritoneal B-1a cells but its oligomer shepherd the cells for IgA response.
MedLine Citation:
PMID:  17570527     Owner:  NLM     Status:  MEDLINE    
Vibrio cholerae hemolysin (HlyA) can exist as a monomer with hemolytic activity and an oligomer that agglutinates erythrocytes. Biochemical differences accompanying the change in state of aggregation led us to weigh possible differences between the two forms from mucosal immunoregulation perspective. HlyA oligomer-treated murine B-1a cells up-regulated TLR2 and involved the signaling molecules MyD88, TRAF6 and NF-kappaB. The cells subsequently expressed IgM and IgA. HlyA monomer treatment although resulted in TLR2 up-regulation, could not induce these effects. Apoptosis was detected in majority of the monomer-treated cells that involved caspase-9 and caspase-3. This study shows for the first time that two forms of the same protein could drive the host immune cell to two different outcomes, one of death and the other towards activation.
Gayatri Mukherjee; Amlan Biswas; Kalyan K Banerjee; Tapas Biswas
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Publication Detail:
Type:  Journal Article     Date:  2007-06-13
Journal Detail:
Title:  Molecular immunology     Volume:  45     ISSN:  0161-5890     ISO Abbreviation:  Mol. Immunol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-09-28     Completed Date:  2007-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905289     Medline TA:  Mol Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  266-70     Citation Subset:  IM    
Division of Immunology and Vaccine Development, National Institute of Cholera and Enteric Diseases, P-33, C.I.T. Road, Scheme XM, Kolkata-700 010, West Bengal, India.
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MeSH Terms
Apoptosis / drug effects*
Bacterial Proteins / chemistry*,  pharmacology*
Hemolysin Proteins / chemistry*,  pharmacology*
Immunoglobulin A / immunology*
Immunoglobulin M / metabolism
Interleukin-5 / pharmacology
Interleukin-6 / pharmacology
Mice, Inbred BALB C
Peritoneum / cytology*,  drug effects*
Protein Structure, Quaternary
RNA, Messenger / genetics,  metabolism
Toll-Like Receptor 2 / genetics,  metabolism
Up-Regulation / drug effects
Vibrio cholerae / chemistry*
Reg. No./Substance:
0/Bacterial Proteins; 0/Hemolysin Proteins; 0/Immunoglobulin A; 0/Immunoglobulin M; 0/Interleukin-5; 0/Interleukin-6; 0/RNA, Messenger; 0/Toll-Like Receptor 2; 0/hemolysin, Vibrio

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