Document Detail


Vibrational spectrometry for the assessment of active substance in metoprolol tablets: a comparison between transmission and diffuse reflectance near-infrared spectrometry.
MedLine Citation:
PMID:  8877855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Near-infrared spectrometry (NIR) was used to quantify metroprolol succinate in controlled release tablets. Metoprolol tablets were made according to an experimental design using different strengths around a central strength of 47.5 mg per tablet. A comparison was made between NIR in the diffuse reflectance mode and the transmission mode. This showed that, although a narrower wavelength range was available in the transmission mode, predictions were much better for models based on transmission spectra than for models based on diffuse reflectance spectra. The main reason for this is that in the reflectance mode NIR spectrometry is very sensitive to the inhomogeneity of the material, while in the transmission mode this problem is less severe. This is due to the larger volume of the material scanned in the transmission mode compared to that in diffuse reflectance. Spectra were taken before and after the tablets were stored under humid conditions. This allowed the final calibration models to be made more robust towards variations in the amount of water in the tablet. Different batches of metoprolol pellets and microcrystalline cellulose were used during the production of the tablets. this resulted in models that were more robust towards possible batch-to-batch differences in the main constituents.
Authors:
J Gottfries; H Depui; M Fransson; M Jongeneelen; M Josefson; F W Langkilde; D T Witte
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  14     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-30     Completed Date:  1997-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1495-503     Citation Subset:  IM    
Affiliation:
Pharmaceutical R&D, Astra Hässle AB, Mölndal, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Drug Storage
Humidity
Metoprolol / analysis*
Spectroscopy, Near-Infrared / methods
Tablets / analysis
Chemical
Reg. No./Substance:
0/Tablets; 37350-58-6/Metoprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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