| Vestibular neurons in the rat contain imidazoleacetic acid-ribotide, a putative neurotransmitter involved in blood pressure regulation. | |
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MedLine Citation:
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PMID: 17278132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A substantial body of research has led to the recognition that the vestibular system participates in blood pressure modulation during active movements and changes in posture, and that this modulation is effected at least partly by the caudal vestibular nuclei. The I-4 isomer of imidazoleacetic acid-ribotide (IAA-RP) is a putative neurotransmitter/modulator that is thought to be an endogenous regulator of general sympathetic drive, particularly systemic blood pressure. The present study employed immunofluorescence and light and electron microscopic immunocytochemistry to visualize IAA-RP in the vestibular nuclei of adult male rats. The results demonstrate IAA-RP immunolabeling of subpopulations of vestibular neurons in the descending nucleus and the caudal half of the medial nucleus, with scattered immunostained vestibular neurons also present more rostrally. On the basis of double immunofluorescence staining for IAA-RP and calbindin, many of these ribotide-immunoreactive neurons appear to be innervated by cerebellar Purkinje cell afferents. Ultrastructural observations in the caudal vestibular nuclei confirm the IAA-RP immunolocalization in cell bodies and dendritic processes, and in some myelinated axons and presynaptic boutons. The regional distribution of IAA-RP immunoreactivity corresponds to the location of vestibular neurons involved in autonomic functions. The presence of IAA-RP in those neurons suggests that they participate specifically in vestibulo-autonomic regulation of blood pressure. The localization of immunostain in processes and terminals suggests that vestibulo-autonomic activity is subject to local feedback control. Overall, the observations offer a chemoanatomic basis for understanding the vestibular side effects commonly experienced by patients treated with clonidine and other imidazoline-related drugs. |
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Authors:
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Giorgio P Martinelli; Victor L Friedrich; George D Prell; Gay R Holstein |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of comparative neurology Volume: 501 ISSN: 0021-9967 ISO Abbreviation: J. Comp. Neurol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-02-12 Completed Date: 2007-05-01 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0406041 Medline TA: J Comp Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 568-81 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. |
Affiliation:
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Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium-Binding Protein, Vitamin D-Dependent / metabolism Citrulline / metabolism Imidazoles Immunohistochemistry / methods Male Microscopy, Immunoelectron / methods Neurons / metabolism*, ultrastructure Rats Rats, Sprague-Dawley Ribosemonophosphates / physiology* Vestibular Nuclei / cytology* |
| Grant Support | |
ID/Acronym/Agency:
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DC01705/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Imidazoles; 0/Ribosemonophosphates; 0/calbindin; 0/imidazoleacetic acid ribotide; 372-75-8/Citrulline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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