| Vestibular neuronal function of cats following unilateral vertebral artery occlusion. | |
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MedLine Citation:
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PMID: 9657307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since vertigo is known to be caused by vertebrobasilar arterial occlusive disease (ex. vertebrobasilar insufficiency; VBI), an electrophysiological study was performed to examine the effects of a unilateral vertebral artery (VA) occlusion on the neuronal activities of the medial vestibular nucleus (MVN) and vestibular ganglion (VG) in alpha-chloralose-anesthetized cats. Single neuronal activity in the MVN and VG was recorded extracellularly with a glass-insulated silver wire microelectrode. When the unilateral VA was occluded for 5 min. the spontaneous firing rate in the MVN was altered as follows. The type A pattern exhibited a transient increase, followed by a decrease. The type B pattern showed a gradual decrease, and no further changes after the onset of occlusion. Type A and B patterns were observed respectively in MVN ipsi- and contra-lateral to the VA occlusion. In contrast, the VG neuronal firing rate was not affected by the occlusion. These results seem to support the clinical suggestion that the vertigo in VBI is produced by a difference in the function between the bilateral vestibular nuclei. rather than by the peripheral vestibular nerve. |
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Authors:
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T Yamanaka; T Yamamoto; H Miyahara; T Matsunaga |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta oto-laryngologica. Supplementum Volume: 533 ISSN: 0365-5237 ISO Abbreviation: Acta Otolaryngol Suppl Publication Date: 1998 |
Date Detail:
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Created Date: 1998-09-16 Completed Date: 1998-09-16 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0370355 Medline TA: Acta Otolaryngol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 26-9 Citation Subset: IM; S |
Affiliation:
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Department of Otolaryngology, Nara Medical University, Kashihara, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cats Electrophysiology Female Male Neurons / physiology* Vertebrobasilar Insufficiency / complications, physiopathology* Vertigo / etiology Vestibular Nerve / physiopathology* Vestibular Nuclei / cytology, physiopathology* |
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