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Vestibular Hair Cells and Afferents: Two Channels for Head Motion Signals.
MedLine Citation:
PMID:  21469959     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Vestibular epithelia of the inner ear detect head motions over a wide range of amplitudes and frequencies. In mammals, afferent nerve fibers from central and peripheral zones of vestibular epithelia form distinct populations with different response dynamics and spike timing. Centralzone afferents are large, fast conduits for phasic signals encoded in irregular spike trains. The finer afferents from peripheral zones conduct more slowly and encode more tonic, linear signals in highly regular spike trains. The hair cells are also of two types, I and II, but the two types do not correspond directly to the two afferent populations. Zonal differences in afferent response dynamics may arise at multiple stages, including mechanoelectrical transduction, voltage-gated channels in hair cells and afferents, afferent transmission at calyceal and bouton synapses, and spike generation in regular and irregular afferents. In contrast, zonal differences in spike timing may depend more simply on the selective expression of low-voltage-activated ion channels by irregular afferents. Expected final online publication date for the Annual Review of Neuroscience Volume 34 is June 17, 2011. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
Authors:
Ruth Anne Eatock; Jocelyn E Songer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-7-21
Journal Detail:
Title:  Annual review of neuroscience     Volume:  -     ISSN:  1545-4126     ISO Abbreviation:  -     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2011-4-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804039     Medline TA:  Annu Rev Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Otology and Laryngology, and Department of Neurobiology, Harvard Medical School, Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA 02114; email: eatock@meei.harvard.edu.
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