| Vessel wall morphometry in giant cell arteritis. | |
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MedLine Citation:
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PMID: 14635297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate morphometrically the relationship between the degree of inflammatory reaction and arterial cross-sectional dimensions in giant cell arteritis (GCA). METHODS: The media and intima of cross-sectioned inflamed arteries from GCA patients were outlined. The media circumference and the media and intima cross-sectional areas were measured. The two segments in every biopsy displaying the least and most widespread media inflammation were compared, using a paired Student's t-test. Moreover, paired comparisons were made of the intima area in inflamed and noninflamed sectors in single cross-sections. RESULTS: The segment in each biopsy showing the most widespread media inflammation had the largest circumference and volume of media and intima; the intima cross-sectional area increased disproportionately. The intima was thickest in inflamed sectors in single cross-sections. CONCLUSION: The close spatial correlation between inflammatory media infiltration and the marked intimal expansion supports the contention that promoting factors produced by inflammatory cells play a pathogenetic role in GCA. |
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Authors:
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C Nordborg; V Petursdottir |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arthritis care and research : the official journal of the Arthritis Health Professions Association Volume: 13 ISSN: 0893-7524 ISO Abbreviation: Arthritis Care Res Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2003-11-25 Completed Date: 2003-12-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8809082 Medline TA: Arthritis Care Res Country: United States |
Other Details:
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Languages: eng Pagination: 286-90 Citation Subset: N |
Affiliation:
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Department of Pathology, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biopsy Female Giant Cell Arteritis / immunology*, pathology* Humans Hyperplasia Inflammation Inflammation Mediators / immunology Male Middle Aged Severity of Illness Index Temporal Arteries / immunology, pathology* Tunica Intima / immunology, pathology* Tunica Media / immunology, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Inflammation Mediators |
| Comments/Corrections | |
Comment On:
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Arthritis Care Res. 2000 Oct;13(5):249-51
[PMID:
14635291
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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