| Vessel wall contrast enhancement: a diagnostic sign of cerebral vasculitis. | |
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MedLine Citation:
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PMID: 18511868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Inflammatory stenoses of cerebral arteries cause stroke in patients with florid vasculitis. However, diagnosis is often difficult even with digital subtraction angiography (DSA) and biopsy. The purpose of this study was to establish the value of contrast-enhanced MRI, proven to be sensitive to extradural arteritis, for the identification of intracranial vessel wall inflammation. PATIENTS AND METHODS: Twenty-seven patients with a diagnosis of cerebral vasculitis affecting large brain vessels were retrieved from the files: 8 children (2-10 years, 7 female, 1 male) and 19 adults (16-76 years, 10 female, 9 male). Diagnosis was based on histological or serological proof of vasculitis or on clinical and imaging criteria. All MRI examinations included diffusion-weighted imaging, time-of-flight magnetic resonance angiography (TOF-MRA) and contrast-enhanced scans. MRI scans were assessed for the presence of ischemic brain lesions, arterial stenoses, vessel wall thickening and contrast uptake. RESULTS: Ischemic changes of the brain tissue were seen in 24/27 patients and restricted diffusion suggestive of recent ischemia in 17/27; 25/27 patients had uni- or multifocal stenoses of intracranial arteries on TOF-MRA and 5/6 had stenoses on DSA. Vessel wall thickening was identified in 25/27, wall enhancement in 23/27 patients. CONCLUSION: Wall thickening and intramural contrast uptake are frequent findings in patients with active cerebral vasculitis affecting large brain arteries. Further prospective studies are required to determine the specificity of this finding. |
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Authors:
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Wilhelm Küker; Susanne Gaertner; Thomas Nagele; Christian Dopfer; Martin Schoning; Jens Fiehler; Peter M Rothwell; Ulrich Herrlinger |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2008-05-30 |
Journal Detail:
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Title: Cerebrovascular diseases (Basel, Switzerland) Volume: 26 ISSN: 1421-9786 ISO Abbreviation: Cerebrovasc. Dis. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-07-02 Completed Date: 2008-09-18 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 9100851 Medline TA: Cerebrovasc Dis Country: Switzerland |
Other Details:
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Languages: eng Pagination: 23-9 Citation Subset: IM |
Copyright Information:
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(c) 2008 S. Karger AG, Basel |
Affiliation:
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Department of Neuroradiology, University of Oxford, John Radcliffe Hospital, Oxford, UK. Wilhelm.Kuker@ndm.ox.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Brain Ischemia / pathology Cerebral Arterial Diseases / pathology Cerebral Arteries / pathology* Child Child, Preschool Contrast Media* Diffusion Magnetic Resonance Imaging* Female Humans Magnetic Resonance Angiography* Male Middle Aged Predictive Value of Tests Reproducibility of Results Retrospective Studies Vasculitis, Central Nervous System / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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