| Vessel imaging with viable tumor analysis for quantification of tumor angiogenesis. | |
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MedLine Citation:
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PMID: 20512867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Imaging of tumor microvasculature has become an important tool for studying angiogenesis and monitoring antiangiogenic therapies. Ultrasmall paramagnetic iron oxide contrast agents for indirect imaging of vasculature offer a method for quantitative measurements of vascular biomarkers such as vessel size index, blood volume, and vessel density. Here, this technique is validated with direct comparisons to ex vivo micro-CT angiography and histologic vessel measurements, showing significant correlations between in vivo vascular MRI measurements and ex vivo structural vessel measurements. The sensitivity of the MRI vascular parameters is also demonstrated, in combination with a multispectral analysis technique for segmenting tumor tissue to restrict the analysis to viable tumor tissue and exclude regions of necrosis. It is shown that this viable tumor segmentation increases sensitivity for detection of significant effects on blood volume and vessel density by two antiangiogenic therapeutics (anti-VEGF and anti-neuropilin-1) on an HM7 colorectal tumor model. Anti-VEGF reduced blood volume by 36 +/- 3% (P < 0.0001) and vessel density by 52 +/- 3% (P < 0.0001) at 48 h posttreatment; the effects of anti-neuropilin-1 were roughly half as strong with a reduction in blood volume of 18 +/- 6% (P < 0.05) and a reduction in vessel density of 33 +/- 5% (P < 0.05) at 48 h posttreatment. |
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Authors:
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Sharon E Ungersma; Glenn Pacheco; Calvin Ho; Sharon Fong Yee; Jed Ross; Nicholas van Bruggen; Franklin V Peale; Sarajane Ross; Richard A D Carano |
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Publication Detail:
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Type: Comparative Study; Journal Article; Validation Studies |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 63 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-23 Revised Date: 2011-03-28 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1637-47 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Tumor Biology and Angiogenesis, Genentech, Inc., South San Francisco, California 94080-4990, USA. ungersma.sharon@gene.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiography* Animals Antineoplastic Agents / therapeutic use Colorectal Neoplasms / drug therapy, radiography* Magnetic Resonance Imaging* / methods Mice Neovascularization, Pathologic / radiography* Sensitivity and Specificity Tomography, X-Ray Computed* Tumor Burden / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
| Comments/Corrections | |
Erratum In:
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Magn Reson Med. 2011 Mar;65(3):889 |
Corrected and Republished In:
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Magn Reson Med. 2011 Mar;65(3):889-99
[PMID:
21442797
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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