Document Detail


Vesiculopustular eruption in a neonate with trisomy 21 syndrome as a clue of transient myeloproliferative disorders.
MedLine Citation:
PMID:  20666188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the case of a vesiculopustular eruption associated with a transient myeloproliferative disorder (TMD) in a neonate with trisomy 21 syndrome. Examination of a skin biopsy showed a dermal mixed inflammatory infiltrate including atypical megakaryoblasts. As the white blood cell count spontaneously normalized, the eruption disappeared. This case report and review of the literature demonstrates that a vesiculopustular eruption could be an important clue to identify TMD in a neonate.
Authors:
Fiammetta Piersigilli; Andrea Diociaiuti; Renata Boldrini; Cinzia Auriti; Marco Curci; Maya El Hachem; Giulio Seganti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cutis; cutaneous medicine for the practitioner     Volume:  85     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  286-8     Citation Subset:  IM    
Affiliation:
Department of Neonatology, Bambino Gesù Children's Hospital, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Down Syndrome / complications*
Female
Humans
Infant, Newborn
Leukocyte Count
Megakaryocyte Progenitor Cells / metabolism
Myeloproliferative Disorders / complications,  diagnosis*,  etiology
Skin Diseases, Vesiculobullous / diagnosis,  etiology*,  pathology

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