Document Detail

Vesicular stomatitis virus-mediated cell fusion subsequent to virus adsorption at different pH values.
MedLine Citation:
PMID:  1668239     Owner:  NLM     Status:  MEDLINE    
Vesicular stomatitis virus (VSV)-mediated cell fusion from without can be induced by transient exposure to low pH, subsequent to adsorption of VSV at neutral pH. To study the mechanism of VSV-induced cell fusion, we examined the effect of pH condition at virus adsorption on acid-inducible VSV-mediated cell fusion. Although the binding of VSV to BHK-21 cells was most efficient under acidic condition (pH 5.7-6.3), extensive cell fusion was not observed under this condition. A temporary exposure to low pH after binding at neutral pH also decreased fusion activity. However, return to neutral pH for 2 min just after the acid binding restored the fusion activity. These results indicate the requirement of neutral pH condition for VSV-mediated cell fusion prior to the acid stimulation which induces conformational change of the virus glycoprotein into a fusogenic form.
S Nagata; T Kurata; Y Ueno; J Chiba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of medical science & biology     Volume:  44     ISSN:  0021-5112     ISO Abbreviation:  Jpn. J. Med. Sci. Biol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-08-20     Completed Date:  1992-08-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0243706     Medline TA:  Jpn J Med Sci Biol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  171-80     Citation Subset:  IM    
Department of Pathology, National Institute of Health, Tokyo.
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MeSH Terms
Cell Fusion / physiology*
Cell Line
Hydrogen-Ion Concentration
Membrane Fusion / physiology
Vesicular stomatitis Indiana virus / physiology*

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