| Vesicular inhibitory amino acid transporter is expressed in gamma-aminobutyric acid (GABA)-containing astrocytes in rat pineal glands. | |
| | |
MedLine Citation:
|
PMID: 15308302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Gamma-aminobutyric acid (GABA) is an inhibitory amino acid and acts as an intercellular transmitter in the central nervous system and peripheral tissues. In pineal glands, GABA is supposed to be a paracrine-like modulator of secretion of melatonin, although its mode of action, especially the sites of GABA signal appearance, is unknown. Vesicular inhibitory amino acid transporter (VIAAT) is a potential marker for the GABAergic phenotype. Here we presented evidence that VIAAT is expressed in GFAP-expressing astrocytes and a subpopulation of OX42-expressing microglia, but not in pinealocytes in cultured cells of rat pineal glands. The VIAAT-expressing cells also exhibit GABA immunoreactivity. Essentially the same results were obtained for pineal glands. These results suggest that GABA is stored and secreted from astrocytes and a subpopulation of microglia in pineal glands. |
| | |
Authors:
|
Noriko Echigo; Yoshinori Moriyama |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuroscience letters Volume: 367 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2004 Aug |
Date Detail:
|
Created Date: 2004-08-13 Completed Date: 2004-11-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
|
Languages: eng Pagination: 79-84 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tshushima-naka, Okayama 700-8530, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Transport Systems
/
genetics,
metabolism* Animals Animals, Newborn Antigens, CD11b / metabolism Astrocytes / metabolism* Blotting, Northern / methods Blotting, Southern / methods Gene Expression Regulation, Developmental / physiology* Glial Fibrillary Acidic Protein / metabolism Male Organ Culture Techniques Pineal Gland / cytology* RNA, Messenger / biosynthesis Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction / methods Synapsins / metabolism Synaptophysin / metabolism Vesicular Inhibitory Amino Acid Transport Proteins Vesicular Transport Proteins / genetics, metabolism* gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acid Transport Systems; 0/Antigens, CD11b; 0/Glial Fibrillary Acidic Protein; 0/RNA, Messenger; 0/Synapsins; 0/Synaptophysin; 0/Vesicular Inhibitory Amino Acid Transport Proteins; 0/Vesicular Transport Proteins; 0/Viaat protein, rat; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diazepam reduces brain lesion size in a photothrombotic model of focal ischemia in rats.
Next Document: Estrogen regulates neprilysin activity in rat brain.