Document Detail

Vesicular Trans-Cell Wall Transport in Fungi: A Mechanism for the Delivery of Virulence-Associated Macromolecules?
MedLine Citation:
PMID:  20617119     Owner:  NLM     Status:  Publisher    
Fungal cells are encaged in rigid, complex cell walls. Until recently, there was remarkably little information regarding the trans-fungal cell wall transfer of intracellular macromolecules to the extracellular space. Recently, several studies have begun to elucidate the mechanisms that fungal cells utilize to secrete a wide variety of macromolecules through the cell wall. The combined use of transmission electron microscopy, serology, biochemistry, proteomics and lipidomics have revealed that the fungal pathogens Cryptococcus neoformans, Histoplasma capsulatum, Candida albicans, Candida parapsilosis and Sporothrix schenckii, as well as the model yeast Saccharomyces cerevisiae, each produces extracellular vesicles that carry lipids, proteins, polysaccharides and pigment-like structures of unquestionable biological significance. Compositional analysis of the C. neoformans and H. capsulatum extracellular vesicles suggests that they may function as 'virulence bags', with the potential to modulate the host-pathogen interaction in favor of the fungus. The cellular origin of the extracellular vesicles remains unknown, but morphological and biochemical features indicate that they are similar to the well-described mammalian exosomes.
Marcio L Rodrigues; Leonardo Nimrichter; Debora L Oliveira; Joshua D Nosanchuk; Arturo Casadevall
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Publication Detail:
Journal Detail:
Title:  Lipid insights     Volume:  2     ISSN:  1178-6353     ISO Abbreviation:  -     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2010-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101512640     Medline TA:  Lipid Insights     Country:  -    
Other Details:
Languages:  ENG     Pagination:  27-40     Citation Subset:  -    
Laboratório de Estudos Integrados em Bioquímica Microbiana, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941590, Brazil.
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Grant Support
R01 AI056070-04//NIAID NIH HHS

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