Document Detail


Vesicular Trans-Cell Wall Transport in Fungi: A Mechanism for the Delivery of Virulence-Associated Macromolecules?
MedLine Citation:
PMID:  20617119     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fungal cells are encaged in rigid, complex cell walls. Until recently, there was remarkably little information regarding the trans-fungal cell wall transfer of intracellular macromolecules to the extracellular space. Recently, several studies have begun to elucidate the mechanisms that fungal cells utilize to secrete a wide variety of macromolecules through the cell wall. The combined use of transmission electron microscopy, serology, biochemistry, proteomics and lipidomics have revealed that the fungal pathogens Cryptococcus neoformans, Histoplasma capsulatum, Candida albicans, Candida parapsilosis and Sporothrix schenckii, as well as the model yeast Saccharomyces cerevisiae, each produces extracellular vesicles that carry lipids, proteins, polysaccharides and pigment-like structures of unquestionable biological significance. Compositional analysis of the C. neoformans and H. capsulatum extracellular vesicles suggests that they may function as 'virulence bags', with the potential to modulate the host-pathogen interaction in favor of the fungus. The cellular origin of the extracellular vesicles remains unknown, but morphological and biochemical features indicate that they are similar to the well-described mammalian exosomes.
Authors:
Marcio L Rodrigues; Leonardo Nimrichter; Debora L Oliveira; Joshua D Nosanchuk; Arturo Casadevall
Related Documents :
8042899 - A novel, "hidden" penicillin-induced death of staphylococci at high drug concentration,...
20022489 - Base-induced delignification of miscanthus x giganteus studied by three-dimensional con...
6347209 - Microscopic studies of candida albicans and torulopsis glabrata after in vitro treatmen...
14732439 - Cell expansion in roots.
7031089 - Variations in properties of nocardia asteroides resulting from growth in the cell wall-...
1180909 - Acetyl groups in cell-wall preparations from higher plants.
19021259 - Conversion of a phase- to a rate-coded position signal by a three-stage model of theta ...
15562619 - Alternative mechanism of eimeria bovis sporozoites to invade cells in vitro by breachin...
409 - Stimulation of 2-deoxy-d-glucose transport in control and virus-transformed cells by et...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Lipid insights     Volume:  2     ISSN:  1178-6353     ISO Abbreviation:  -     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2010-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101512640     Medline TA:  Lipid Insights     Country:  -    
Other Details:
Languages:  ENG     Pagination:  27-40     Citation Subset:  -    
Affiliation:
Laboratório de Estudos Integrados em Bioquímica Microbiana, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941590, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 AI056070-04//NIAID NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Quantitative Accuracy of HRRT List-mode Reconstructions: Effect of Low Statistics.
Next Document:  A Time Varying Evaluation of Identity Theory and Father Involvement for Full Custody, Shared Custody...