Document Detail

Vesicoureteral reflux: subpopulations of patients defined by clinical variables.
MedLine Citation:
PMID:  10663525     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The first imaging evaluation of the child with urinary tract infection (UTI) is often the same for all children, regardless of the child's clinical presentation. However, this approach is simplistic and ignores considerable differences in the frequency of abnormal pathophysiology in different subpopulations of children with UTI. OBJECTIVE: Six clinical variables are evaluated as predictors of vesicoureteral reflux (VUR) in a large series of girls with UTI. MATERIALS AND METHODS: Data were collected from a consecutive series of 919 girls undergoing a first imaging evaluation for UTI. Six input variables were used: age, maximum body temperature (T(max)), number of UTIs, hospitalization, family history of childhood UTI, and rapidity of response to antibiotic therapy. The dependent variable was VUR. Data were enumerated and analyzed by logistic regression and the chi-square test. RESULTS: VUR was present in 28.8 %. The percentage with VUR varied from 56.1 % for age < 6 months and T(max) L 38.5 degrees C to 13.0 % for age L 10 years and T(max) < 38.5 degrees C. The frequency of VUR was significantly lower in girls with T(max) < 38.5 degrees C in most age groups. Logistic regression demonstrated, when all clinical variables were taken together, that only age and T(max) were independent predictors of VUR. CONCLUSIONS: Girls with UTI should not be considered to be a homogeneous group. The frequency of VUR is related to T(max) and inversely to age. Data about these subpopulations should be used in deciding which girls should undergo cystography.
M J Gelfand; B L Koch; G G Cordero; A Salmanzadeh; P S Gartside
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric radiology     Volume:  30     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-06-01     Completed Date:  2000-06-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  121-4     Citation Subset:  IM    
Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229-3039, USA.
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MeSH Terms
Chi-Square Distribution
Child, Preschool
Infant, Newborn
Logistic Models
Prospective Studies
Urinary Tract Infections / diagnosis,  etiology
Vesico-Ureteral Reflux / complications,  diagnosis,  epidemiology*

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