| Vesicles associated with calcification in the matrix of epiphyseal cartilage. | |
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MedLine Citation:
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PMID: 5775794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vesicles have been identified within the cartilage matrix of the upper tibial epiphyseal plate of normal mice. They were seen at all levels within the plate and usually did not appear to be in contact with cartilage cells. Vesicles were concentrated within the matrix of the longitudinal septa from the proliferative zone downward. They varied considerably in size ( approximately 300 A to approximately 1 micro) and in shape. They were bounded by unit membranes, and contained materials of varying density including, rarely, ribosomes. A close association was demonstrated between matrix vesicles and calcification: in the lower hypertrophic and calcifying zones of the epiphysis, vesicles were found in juxtaposition to needle-like structures removed by demineralization with ethylenediaminetetraacetate and identified by electron diffraction as hydroxyapatite and/or fluorapatite crystal structure-the former being indistinguishable from the latter for most cases in which electron diffraction methods are employed. Decalcification also revealed electron-opaque, partially membrane-bounded structures within previously calcified cartilage of the epiphyseal plate and underlying metaphysis which corresponded in size and distribution to matrix vesicles. It is suggested that matrix vesicles are derived from cells and that they may play a role in initiating calcification at the epiphysis. |
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Authors:
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H C Anderson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of cell biology Volume: 41 ISSN: 0021-9525 ISO Abbreviation: J. Cell Biol. Publication Date: 1969 Apr |
Date Detail:
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Created Date: 1969-05-08 Completed Date: 1969-05-08 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0375356 Medline TA: J Cell Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 59-72 Citation Subset: IM; S |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apatites Calcification, Physiologic* Cartilage / cytology* Epiphyses / cytology* Membranes Mice Microscopy, Electron Ribosomes Tibia / cytology |
| Chemical | |
Reg. No./Substance:
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0/Apatites |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Cell Biol ISSN: 0021-9525 ISSN: 1540-8140 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1969 by The Rockefeller University Press. Received Day: 30 Month: 4 Year: 1968 Revision Received Day: 18 Month: 11 Year: 1968 Print publication date: Day: 1 Month: 4 Year: 1969 Volume: 41 Issue: 1 First Page: 59 Last Page: 72 ID: 2107736 PubMed Id: 5775794 |
| VESICLES ASSOCIATED WITH CALCIFICATION IN THE MATRIX OF EPIPHYSEAL CARTILAGE | |
| H. Clarke Anderson | |
| From the Department of Pathology, State University of New York Downstate Medical Center, Brooklyn, New York 11203 |
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