Document Detail


Vesicles as pseudostationary phase for enantiomer separation by capillary electrophoresis.
MedLine Citation:
PMID:  15861803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A vesicle-forming single-tailed amino acid derivatized surfactant, sodium N-(4-n-dodecyloxybenzoyl)-L-valinate (SDLV) has been used as a chiral selector in micellar electrokinetic chromatography to study the molecular recognition of sterically hindered atropisomeric compounds (+/-)binaphthol, (+/-)binaphthyl diamine, (+/-)binaphthol phosphate, Tröger's base and the chiral compound benzoin (BZN). The aggregation behavior and microstructure of the surfactant were studied in separation buffer. The amphiphile was found to form bilayer vesicles in dilute aqueous solutions. The chromatographic separation of enantiomers by use of large liposome-like vesicles spontaneously formed by the amphiphile was explored. The separations were optimized with respect to voltage, pH, and surfactant and buffer concentrations. The resolutions obtained for the above mentioned racemates by use of SDLV vesicles as chiral selectors are higher compared to those reported for other chiral surfactant monomers. The results have been discussed in light of the aggregation behavior of the amphiphile in buffered aqueous solutions.
Authors:
Ashok Mohanty; Joykrishna Dey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of chromatography. A     Volume:  1070     ISSN:  0021-9673     ISO Abbreviation:  J Chromatogr A     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-09-29     Revised Date:  2009-01-15    
Medline Journal Info:
Nlm Unique ID:  9318488     Medline TA:  J Chromatogr A     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  185-92     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India.
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MeSH Terms
Descriptor/Qualifier:
Buffers
Electrophoresis, Capillary / methods*
Hydrogen-Ion Concentration
Microscopy, Electron, Transmission
Stereoisomerism
Surface-Active Agents / chemistry
Chemical
Reg. No./Substance:
0/Buffers; 0/Surface-Active Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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