Document Detail

Very low maternal serum chorionic gonadotropin levels in association with fetal triploidy.
MedLine Citation:
PMID:  7507646     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study was to identify the parental origin of the extra haploid set of chromosomes in triploid pregnancies and to correlate the parental origin to very low levels of human chorionic gonadotropin and unconjugated estriol levels (multiple of the median < or = 0.20) and normal alpha-fetoprotein levels. STUDY DESIGN: Three triploid pregnancies were ascertained retrospectively, and three pregnancies were identified prospectively. Maternal sera samples were analyzed for levels of alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol. Deoxyribonucleic acid analysis was performed on parental bloods and fetal fibroblasts in two prospectively identified pregnancies to establish the parental origin of the extra set of chromosomes. RESULTS: Levels of alpha-fetoprotein were normal in all pregnancies. Levels of human chorionic gonadotropin were very low in five of six of pregnancies, and unconjugated estriol levels were low in three of six pregnancies. Deoxyribonucleic acid analysis indicated maternal origin of the extra haploid set of chromosomes in two triploids. CONCLUSION: When the extra haploid set of chromosomes are maternally derived, some triploid pregnancies exhibit very low levels of maternal serum human chorionic gonadotropin and unconjugated estriol with normal levels of alpha-fetoprotein.
D Schmidt; L G Shaffer; C McCaskill; E Rose; F Greenberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  170     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-03-01     Completed Date:  1994-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  AIM; IM    
Institute for Molecular Genetics, Baylor College of Medicine, Houston, TX 77030.
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MeSH Terms
Chorionic Gonadotropin / blood*
Chromosome Aberrations / diagnosis*
Chromosome Disorders
Estriol / blood
Fetal Growth Retardation / ultrasonography
Genetic Markers
Polymerase Chain Reaction
Pregnancy / blood*
Pregnancy Trimester, Second
Prenatal Diagnosis*
Prospective Studies
Retrospective Studies
Ultrasonography, Prenatal
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Genetic Markers; 0/alpha-Fetoproteins; 50-27-1/Estriol

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