Document Detail

Very low frequency power of heart rate variability is a powerful predictor of clinical prognosis in patients with congestive heart failure.
MedLine Citation:
PMID:  15056832     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The present study examined whether the very low frequency (VLF) power of heart rate variability (HRV) is predictive of clinical prognosis in patients with congestive heart failure (CHF). METHOD AND RESULTS: The study recruited 54 consecutive CHF patients with emergency admission because of exacerbation of pulmonary congestion. Holter monitoring was performed after improvement of pulmonary congestion. The frequency components of HRV were calculated in the frequency domain (VLF, low frequency (LF), high frequency (HF), total power (TP) and the ratio of LF to HF power). The left ventricular ejection fraction was calculated, and plasma brain natriuretic peptide (BNP) and norepinephrine were also measured at discharge. Within a mean follow-up period of 19.8 +/- 11.7 months, 18 patients experienced cardiovascular events; 7 patients died and 11 patients required rehospitalization because of worsening of CHF. In univariate analysis, diabetes mellitus (DM), BNP and New York Heart Association (NYHA) functional class were significant as risk factors for cardiac events. VLF power, LF power and TP were the strong predictors for cardiac events in HRV. In multivariate analysis, VLF power predicted cardiac events independently of LF power, TP, DM, BNP and NYHA functional class (chi-square=6.24, p=0.01). CONCLUSIONS: VLF power is an independent risk predictor in patients with CHF.
Mitsuyoshi Hadase; Akihiro Azuma; Kan Zen; Satoshi Asada; Tatsuya Kawasaki; Tadaaki Kamitani; Shingo Kawasaki; Hiroki Sugihara; Hiroaki Matsubara
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  68     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-01     Completed Date:  2004-10-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  343-7     Citation Subset:  IM    
Department of Cardiology, Kyoto Prefectural University of Medicine, Japan.
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MeSH Terms
Aged, 80 and over
Cheyne-Stokes Respiration / epidemiology
Cohort Studies
Disease Progression
Disease-Free Survival
Electrocardiography, Ambulatory
Follow-Up Studies
Heart Failure / blood,  mortality,  physiopathology*
Heart Rate*
Life Tables
Middle Aged
Norepinephrine / blood
Predictive Value of Tests
Prospective Studies
Risk Factors
Survival Analysis
Reg. No./Substance:

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