Document Detail

Very late paclitaxel-eluting stent thrombosis despite 21 months of clopidogrel treatment after percutaneous coronary intervention.
MedLine Citation:
PMID:  17667035     Owner:  NLM     Status:  MEDLINE    
Drug-eluting stents (DES) present a slightly higher incidence of stent thrombosis compared to bare metal stents and some cases of DES thrombosis are described in the literature. Therefore, there is consensus in recommending treatment with clopidogrel for at least 6 months in addition to life-long aspirin administration. We describe a case of very late paclitaxel-eluting stent thrombosis despite 21 months of clopidogrel treatment, which occurred just 2 weeks after its withdrawal, causing an acute coronary syndrome that was promptly resolved with an urgent invasive strategy. In our experience, paclitaxel-eluting stent thrombosis can occur several months after stent implantation despite prolonged clopidogrel treatment.
Gennaro Sardella; Chiara Bucciarelli-Ducci; Massimo Mancone; Riccardo Colantonio; Giuseppe Massimo Sangiorgi; Francesco Fedele
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  8     ISSN:  1558-2027     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-21     Revised Date:  2009-05-28    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-8     Citation Subset:  IM    
Department of Cardiovascular and Respiratory Sciences, Policlinico Umberto I, University of Rome, La Sapienza, Rome, Italy.
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MeSH Terms
Acute Disease
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects*,  instrumentation
Cardiovascular Agents / administration & dosage*
Coronary Angiography
Coronary Thrombosis / complications,  etiology*,  prevention & control,  radiography
Middle Aged
Myocardial Ischemia / etiology*,  radiography
Paclitaxel / administration & dosage*
Platelet Aggregation Inhibitors / therapeutic use*
Practice Guidelines as Topic
Prosthesis Design
Ticlopidine / analogs & derivatives*,  therapeutic use
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Cardiovascular Agents; 0/Platelet Aggregation Inhibitors; 33069-62-4/Paclitaxel; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel

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