| Very high frequency oscillations (over 1000 Hz) in human epilepsy. | |
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MedLine Citation:
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PMID: 20471308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: High frequency oscillations (HFO) of 100-500Hz have been reported in epileptic human brain. However, the questions of how fast these oscillations can reach, and which frequency range is clinically important remain unanswered. We recorded interictal and ictal very high frequency oscillations (VHFO) of 1000-2500Hz by subdural electrodes using 10kHz sampling rate. We describe the characteristics of VHFO, and discuss their underlying mechanism and clinical significance. METHODS: Five patients with neocortical epilepsy were studied. All patients underwent intracranial EEG monitoring with subdural electrodes. EEG recording with sampling rate of 10kHz was conducted. Histopathology revealed malformation of cortical development in all cases. RESULTS: In four of five patients, very high frequency activities of 1000-2500Hz were detected in highly localized cortical regions (one to four electrodes in individual patient). We named these activities "very high frequency oscillations (VHFO)". Interictally, VHFO appeared intermittently, and were interrupted by spikes. Sustained VHFO without spikes appeared around the start of seizures. CONCLUSIONS: Both interictal and ictal VHFO can be recorded by subdural electrodes. Compared to HFO previously reported, VHFO have much higher frequency, more restricted distribution, smaller amplitude, and different timing of onset. SIGNIFICANCE: Recording of VHFO may be useful for identifying the epileptogenic zone. |
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Authors:
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Naotaka Usui; Kiyohito Terada; Koichi Baba; Kazumi Matsuda; Fumihiro Nakamura; Keiko Usui; Takayasu Tottori; Shuichi Umeoka; Shigeru Fujitani; Tadahiro Mihara; Yushi Inoue |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-05-14 |
Journal Detail:
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Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 121 ISSN: 1872-8952 ISO Abbreviation: Clin Neurophysiol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883319 Medline TA: Clin Neurophysiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1825-31 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan. n-usui@szec.hosp.go.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Clocks / physiology* Brain Mapping / methods Electrodes, Implanted Electroencephalography / methods* Epilepsy / diagnosis*, physiopathology* Humans Subdural Space / physiology Young Adult |
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