Document Detail

Very low birth weight infants born to cytomegalovirus-seropositive mothers fed with their mother's milk: a prospective study.
MedLine Citation:
PMID:  19230896     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the risk of post-natal cytomegalovirus (CMV) transmission to very low birth weight (VLBW) infants fed with their mother's fresh milk. STUDY DESIGN: Prospective, observational study of 80 VLBW infants and their 68 mothers. Infants' urine and their own mother's fresh breast milk were tested for CMV by means of culture tests once a week until discharge. CMV in infected milk and urine were genotyped. The clinical course, laboratory findings, and outcome of infants infected with CMV at 2 years of age are reported. RESULTS: Fifty-three mothers (78%) were CMV-seropositive at delivery. CMV was detected in the milk of 21 of 53 seropositive mothers (40%), and CMV was in the urine in 9 of 26 infants (35%) fed with CMV-positive milk. The same gN-genotype was found in milk and urine. Three infected infants <28 weeks gestational age (GA) had a mild sepsis-like illness. Five more infants had neutropenia, conjugated hyperbilirubinaemia, or both. Post-natal CMV infection occurred in 1 of 19 infants with a GA<28 weeks who were treated at birth with intravenous immunoglobulin versus 3 of 5 non-treated infants (P < .02). Symptomatic CMV infection was associated with bronchopulmonary dysplasia. No neurosensorial sequelae were found at 2 years of corrected age. CONCLUSIONS: CMV infection via fresh human milk is mild, self-limiting, and without sequelae. Very-low GA and pre-existing chronic diseases are associated with symptomatic infection.
Maria Grazia Capretti; Marcello Lanari; Tiziana Lazzarotto; Liliana Gabrielli; Sara Pignatelli; Luigi Corvaglia; Elisabetta Tridapalli; Giacomo Faldella
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Publication Detail:
Type:  Journal Article     Date:  2009-02-23
Journal Detail:
Title:  The Journal of pediatrics     Volume:  154     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  842-8     Citation Subset:  AIM; IM    
Department of Obstetrical, Gynecological, and Pediatric Sciences, Operative Unit of Neonatology, St. Orsola-Malpighi General Hospital, University of Bologna, Bologna, Italy.
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MeSH Terms
Antibodies, Viral / blood
Cytomegalovirus / immunology,  isolation & purification*
Cytomegalovirus Infections / diagnosis,  transmission*
DNA, Viral / analysis
Infant, Newborn
Infant, Very Low Birth Weight*
Infectious Disease Transmission, Vertical*
Milk, Human / virology*
Pregnancy Complications, Infectious / virology
Urine / virology
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral
Comment In:
J Pediatr. 2009 Jun;154(6):A1   [PMID:  19446083 ]

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