| Very low birth weight infants born to cytomegalovirus-seropositive mothers fed with their mother's milk: a prospective study. | |
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MedLine Citation:
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PMID: 19230896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the risk of post-natal cytomegalovirus (CMV) transmission to very low birth weight (VLBW) infants fed with their mother's fresh milk. STUDY DESIGN: Prospective, observational study of 80 VLBW infants and their 68 mothers. Infants' urine and their own mother's fresh breast milk were tested for CMV by means of culture tests once a week until discharge. CMV in infected milk and urine were genotyped. The clinical course, laboratory findings, and outcome of infants infected with CMV at 2 years of age are reported. RESULTS: Fifty-three mothers (78%) were CMV-seropositive at delivery. CMV was detected in the milk of 21 of 53 seropositive mothers (40%), and CMV was in the urine in 9 of 26 infants (35%) fed with CMV-positive milk. The same gN-genotype was found in milk and urine. Three infected infants <28 weeks gestational age (GA) had a mild sepsis-like illness. Five more infants had neutropenia, conjugated hyperbilirubinaemia, or both. Post-natal CMV infection occurred in 1 of 19 infants with a GA<28 weeks who were treated at birth with intravenous immunoglobulin versus 3 of 5 non-treated infants (P < .02). Symptomatic CMV infection was associated with bronchopulmonary dysplasia. No neurosensorial sequelae were found at 2 years of corrected age. CONCLUSIONS: CMV infection via fresh human milk is mild, self-limiting, and without sequelae. Very-low GA and pre-existing chronic diseases are associated with symptomatic infection. |
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Authors:
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Maria Grazia Capretti; Marcello Lanari; Tiziana Lazzarotto; Liliana Gabrielli; Sara Pignatelli; Luigi Corvaglia; Elisabetta Tridapalli; Giacomo Faldella |
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Publication Detail:
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Type: Journal Article Date: 2009-02-23 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 154 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-18 Completed Date: 2009-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 842-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrical, Gynecological, and Pediatric Sciences, Operative Unit of Neonatology, St. Orsola-Malpighi General Hospital, University of Bologna, Bologna, Italy. mariagrazia.capretti@virgilio.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Viral
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blood Cytomegalovirus / immunology, isolation & purification* Cytomegalovirus Infections / diagnosis, transmission* DNA, Viral / analysis Female Humans Infant Infant, Newborn Infant, Very Low Birth Weight* Infectious Disease Transmission, Vertical* Male Milk, Human / virology* Pregnancy Pregnancy Complications, Infectious / virology Urine / virology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/DNA, Viral |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2009 Jun;154(6):A1
[PMID:
19446083
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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