| A very high prevalence of low HDL cholesterol in Spanish patients with acute coronary syndromes. | |
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MedLine Citation:
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PMID: 20641119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Total and low-density lipoprotein cholesterol (LDL-C) concentrations in coronary artery disease have progressively declined, although high-density lipoprotein cholesterol (HDL-C) has not always been evaluated. The prevalence and related factors of low HDL-C in a cohort of Spanish patients with acute coronary syndromes (ACS) were assessed. METHODS: Clinical and laboratory data registered at admission and at discharge of 648 patients admitted to coronary care units of 6 Spanish hospitals for ACS between January 2004 and September 2007 were analyzed. RESULTS: Low HDL-C (HDL-C < 1.04 mmol/L) was observed in 367 (56.6%) patients. Male gender, smoking, hypertension, diabetes, high body mass index, and triglycerides were related to low HDL-C. Female gender was the strongest protective factor against low HDL-C (0.619; 95% confidence interval [CI]: 0.410-0.934; P = 0.022), whereas high triglycerides (1.653; 95% CI: 1.323-2.064; P < 0.001) followed by previous ischemic disease (1.504; 95% CI: 1.073-2.110; P = 0.018) were the strongest factors associated with low HDL-C. One-third of patients were taking statins at admission, but only 2% were on fibrate therapy. A large increase in statin therapy, but not in other hypolipemiant drug therapy, between admission and discharge was noted in the whole cohort and among patients with low HDL-C. CONCLUSION: Spanish patients with ACS have a very high prevalence of low HDL-C. Male gender, high triglycerides, and previous ischemic disease are strong, independent factors associated with this disorder. As low HDL-C remains almost completely untreated in ACS, strategies to enhance the treatment of this lipoprotein abnormality are urgently required. |
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Authors:
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Xavier Pintó; Jesús Millán; Anna Muñoz; Emili Corbella; Antonio Hernández-Mijares; Manuel Zuñiga; Alipio Mangas; Juan Pedro-Botet |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Clinical cardiology Volume: 33 ISSN: 1932-8737 ISO Abbreviation: Clin Cardiol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 418-23 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Wiley Periodicals, Inc. |
Affiliation:
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Unitat de Lípids i Risc Vascular, Servei de Medicina Interna, Hospital Universitari de Bellvitge, Barcelona, Spain. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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blood,
epidemiology* Aged Biological Markers / blood Chi-Square Distribution Cholesterol, HDL / blood* Down-Regulation Dyslipidemias / blood, drug therapy, epidemiology* Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Logistic Models Male Middle Aged Myocardial Ischemia / epidemiology Patient Admission Patient Discharge Prevalence Risk Assessment Risk Factors Sex Factors Spain / epidemiology Time Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cholesterol, HDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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