Document Detail

Vertigo as the first sign of chronic myeloid leukemia: a case report and literature review.
MedLine Citation:
PMID:  23476855     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Acute vestibular deficit as the first sign of leukemia is extremely rare. The literature shows some cases of sudden hearing loss accompanied by instability and associated with hyperviscosity syndrome. We present the case of a patient who presents a harmonic vestibular deficit of the right ear. The complementary studies revealed an abnormally high level of leukocytes. A peripheral blood cytogenetic analysis is performed due to a high suspicion of leukemia, and the results show BCR/ABL fusion gene with a cut point in the M-BCR region, which confirms the diagnosis of chronic myeloid leukemia. In this case we detail the importance of taking hematological disorders into consideration in the differential diagnosis of patients with otoneurological symptoms, and we also review the etiopathogenic mechanisms, symptoms, diagnosis, and therapeutic options for chronic myeloid leukemia with sudden hearing loss and vertigo.
Rubén Martín-Hernández; Diego Hernando Macías-Rodríguez; Víctor Martín-Sánchez; Cristina Cordero-Civantos; Santiago Santa Cruz-Ruiz; Angel Batuecas-Caletrio
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Publication Detail:
Type:  Journal Article     Date:  2013-02-12
Journal Detail:
Title:  Case reports in otolaryngology     Volume:  2013     ISSN:  2090-6765     ISO Abbreviation:  Case Rep Otolaryngol     Publication Date:  2013  
Date Detail:
Created Date:  2013-03-11     Completed Date:  2013-03-12     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  101576603     Medline TA:  Case Rep Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505636     Citation Subset:  -    
Otoneurology Unit, Department of Otorhinolaryngology and Head and Neck Pathology, University Hospital of Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, Spain.
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