| Vertical and horizontal transmission of unique Candida species to premature newborns. | |
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MedLine Citation:
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PMID: 8722935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The number of nosocomial bloodstream infections due to Candida species in critically ill newborns is increasing. This pathogen may be vertically transmitted from the mother or nosocomially acquired in the nursery. The goal of this study was to identify the route of transmission of unique Candida species and strains from mothers to their preterm offspring. Specimens from mothers for fungal cultures were obtained before delivery, and specimens from infants for sequential fungal cultures were obtained at defined intervals. Candida species were identified by standard methods and were typed by electrophoretic karyotyping (EK) and restriction endonuclease analysis of genomic DNA (REAG) with pulsed-field gel electrophoresis. Antifungal susceptibility testing was performed on all isolates. Fungal cultures were positive for Candida species in 12 (63%) of 19 mothers' specimens and in seven (33%) of 21 infants' specimens. EK and REAG revealed that both the mother and the infant in three (14%) of 21 mother-infant pairs were colonized with the identical strain of Candida albicans. C. albicans was most commonly transmitted vertically. Candida parapsilosis colonized other infants and could not be accounted for by a maternal reservoir. |
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Authors:
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L A Waggoner-Fountain; M W Walker; R J Hollis; M A Pfaller; J E Ferguson; R P Wenzel; L G Donowitz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 22 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-10-24 Completed Date: 1996-10-24 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 803-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Virginia, Charlottesville, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Candida
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classification,
genetics,
isolation & purification Candida albicans / genetics, isolation & purification Candidiasis / epidemiology, microbiology, transmission* Cross Infection / epidemiology, microbiology, transmission* DNA Restriction Enzymes DNA, Fungal / genetics, isolation & purification Disease Transmission, Infectious Electrophoresis, Gel, Pulsed-Field Female Humans Infant, Newborn Infant, Premature Infectious Disease Transmission, Vertical Karyotyping Male Molecular Epidemiology Pregnancy Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/DNA, Fungal; EC 3.1.21.-/DNA Restriction Enzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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