Document Detail


Verteporfin therapy for choroidal hemangioma: a long-term follow-up.
MedLine Citation:
PMID:  16141856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To document the long-term follow-up of patients with circumscribed choroidal hemangioma who were treated with verteporfin photodynamic therapy (PDT). METHODS: Fifteen patients were included in a prospective interventional case series. Verteporfin PDT as a bolus infusion of 6 mg/m body surface area and a light dose of 100 J/cm at 689 nm applied over 166 seconds were administered. Standardized evaluation was performed every 3 months within the first year and at 12-month intervals during follow-up. RESULTS: At baseline, all patients presented with significant vision loss ranging from 20/26 to 20/500. During a mean follow-up of 36.6 months (range, 12-66 months), no patient had evidence of recurrence. Mean final visual acuity ranged from 20/20 to 20/400. In all patients, complete and permanent regression with no signs of tumor regrowth or recurring subretinal fluid was found. Of 15 patients, 13 had a substantial increase in visual acuity (range, 2-9 lines), and 2 patients' visual acuity remained stable. Chorioretinal atrophy at the previous tumor site did not enlarge over time. Retreatments after completion of the primary treatment were not necessary. CONCLUSION: Persistent and complete absence of choroidal hemangioma associated with persistent improvement in visual acuity and central visual fields can be obtained with verteporfin PDT.
Authors:
Stephan Michels; Rike Michels; Christian Simader; Ursula Schmidt-Erfurth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  25     ISSN:  0275-004X     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-09-27     Revised Date:  2006-12-15    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  697-703     Citation Subset:  IM    
Affiliation:
University Eye Hospital Vienna, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Choroid Neoplasms / drug therapy*,  pathology,  ultrasonography
Fluorescein Angiography
Follow-Up Studies
Hemangioma / drug therapy*,  pathology,  ultrasonography
Humans
Indocyanine Green / diagnostic use
Photochemotherapy*
Photosensitizing Agents / therapeutic use*
Porphyrins / therapeutic use*
Prospective Studies
Treatment Outcome
Visual Acuity
Chemical
Reg. No./Substance:
0/Photosensitizing Agents; 0/Porphyrins; 129497-78-5/verteporfin; 3599-32-4/Indocyanine Green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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