Document Detail

Vertebrobasilar dolichoectasia as a risk factor for cerebral microbleeds.
MedLine Citation:
PMID:  23294009     Owner:  NLM     Status:  Publisher    
BACKGROUND: Both vertebrobasilar dolichoectasia (VBD) and cerebral microbleeds (CMBs) are related with the risk of intracerebral hemorrhage. We aimed to examine the relationship between the VBD and CMB in ischaemic stroke patients. METHODS: A consecutive series of 182 patients hospitalized because of ischaemic stroke or transient ischaemic attack (TIA), and who underwent gradient echo brain magnetic resonance imaging were retrospectively recruited from a prospective stroke registry. CMB locations were categorized into anterior and posterior circulation. Ectasia was defined as basilar artery (BA) diameter > 4.5 mm, and dolichosis, as either BA bifurcation above the suprasellar cistern or lateral to the margin of the clivus or dorsum sellae. Whether VBD is associated with CMB anywhere in the brain or in anterior or posterior circulation territories was analysed using binary and multinomial logistic regression models. RESULTS: Twenty-four subjects (13.2%) had VBD and 48 (26.4%) had CMBs. CMBs were more frequently observed in patients with VBD than without (66.7% vs. 20.3%, P < 0.001). VBD was significantly associated with CMBs in any location (crude odds ratio, 7.88; 95% confidence interval, 3.10-20.02), in the posterior circulation territory only (9.63; 2.60-34.94), and in both territories (9.25; 3.40-26.29), but not in the anterior circulation only (1.14; 0.009-11.20). These associations remained unchanged after adjusting for age, gender, hypertension, leukoaraiosis and stroke subtype. CONCLUSIONS: VBD in patients with ischaemic stroke or TIA is independently associated with CMBs, especially in the posterior circulation territory.
J-M Park; J-S Koo; B-K Kim; O Kwon; J J Lee; K Kang; J S Lee; J Lee; H-J Bae
Related Documents :
24604959 - Cyclin d1 expression in multiple myeloma by immunohistochemistry: case series of 14 pat...
4063189 - Neutrophil and monocyte chemotaxis in pustulosis palmo-plantaris and pustular psoriasis.
24703459 - Determinants of urolithiasis before and after parathyroidectomy in patients with primar...
24963969 - Melkersson-rosenthal syndrome: a retrospective study of 44 patients.
23756109 - Bone mineral density differences between femurs of scoliotic patients undergoing dual-...
24575109 - Low-density lipoprotein and intracerebral hematoma expansion in daily alcohol users.
25465029 - Temporal lobe epilepsy and emotion recognition without amygdala: a case study of urbach...
7783069 - Visceral larva migrans mimicking rheumatic diseases.
3109229 - Efficacy and safety of flecainide acetate for atrial tachycardia or fibrillation.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  -     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Author(s) European Journal of Neurology © 2013 EFNS.
Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Spiroketal Formation and Modification in Avermectin Biosynthesis Involves a Dual Activity of AveC.
Next Document:  Phenotypic variability in resting-state functional connectivity: current status.