Document Detail


Vertebrate left-right asymmetry: old studies and new insights.
MedLine Citation:
PMID:  10512183     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During vertebrate embryonic development, the organs of the chest and abdomen, heart, lung and gastrointestinal tract, acquire characteristic asymmetric positions with respect to the left-right body axis. In the beginning of the 20th century Hans Spemann and his co-workers described manipulations of amphibian embryos which resulted in inversion of organ laterality in a predictable manner. Hedwig Wilhelmi concluded from these experiments that determinants on the left side of the embryo specify laterality, and Meyer postulated that a mediator should transfer this positional information to the forming heart. In this review we discuss the classical experiments in the light of recent advances in the molecular understanding of left-right development, with a focus on the mediator role of the homeobox gene Pitx2.
Authors:
M Blum; H Steinbeisser; M Campione; A Schweickert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cellular and molecular biology (Noisy-le-Grand, France)     Volume:  45     ISSN:  0145-5680     ISO Abbreviation:  Cell. Mol. Biol. (Noisy-le-grand)     Publication Date:  1999 Jul 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9216789     Medline TA:  Cell Mol Biol (Noisy-le-grand)     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  505-16     Citation Subset:  IM    
Affiliation:
Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, Germany. martin.blum@itg.fzk.de
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MeSH Terms
Descriptor/Qualifier:
Amphibians / embryology
Animals
Body Patterning / physiology*
Developmental Biology / methods*,  trends
Embryo, Nonmammalian
Functional Laterality
Gene Expression Regulation, Developmental
Homeodomain Proteins / genetics,  metabolism
Morphogenesis
Nodal Protein
Nuclear Proteins*
Paired Box Transcription Factors
Signal Transduction*
Transcription Factors / genetics,  metabolism
Transforming Growth Factor beta / genetics,  metabolism
Vertebrates / embryology*
Chemical
Reg. No./Substance:
0/Homeodomain Proteins; 0/Nodal Protein; 0/Nuclear Proteins; 0/Paired Box Transcription Factors; 0/Transcription Factors; 0/Transforming Growth Factor beta; 0/homeobox protein PITX1; 0/homeobox protein PITX3; 184787-43-7/homeobox protein PITX2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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