Document Detail


Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension.
MedLine Citation:
PMID:  23143599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cystic kidney diseases are a global public health burden, affecting over 12 million people. Although much is known about the genetics of kidney development and disease, the cellular mechanisms driving normal kidney tubule elongation remain unclear. Here, we used in vivo imaging to show for the first time that mediolaterally oriented cell intercalation is fundamental to vertebrate kidney morphogenesis. Unexpectedly, we found that kidney tubule elongation is driven in large part by a myosin-dependent, multicellular rosette-based mechanism, previously only described in Drosophila melanogaster. In contrast to findings in Drosophila, however, non-canonical Wnt and planar cell polarity (PCP) signaling is required to control rosette topology and orientation during vertebrate kidney tubule elongation. These data resolve long-standing questions concerning the role of PCP signaling in the developing kidney and, moreover, establish rosette-based intercalation as a deeply conserved cellular engine for epithelial morphogenesis.
Authors:
Soeren S Lienkamp; Kun Liu; Courtney M Karner; Thomas J Carroll; Olaf Ronneberger; John B Wallingford; Gerd Walz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-11
Journal Detail:
Title:  Nature genetics     Volume:  44     ISSN:  1546-1718     ISO Abbreviation:  Nat. Genet.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-02-13     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1382-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement
Cell Polarity*
Drosophila melanogaster
Female
Kidney Diseases, Cystic / embryology*
Kidney Tubules / embryology
Microscopy, Confocal / methods
Morphogenesis
Signal Transduction
Xenopus
Grant Support
ID/Acronym/Agency:
1R01DK080004/DK/NIDDK NIH HHS; P30DK079328/DK/NIDDK NIH HHS; R01 GM074104/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute
Comments/Corrections

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