Document Detail


Vertebrate cell cycle modulates infection by protozoan parasites.
MedLine Citation:
PMID:  7029713     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Synchronized HeLa cell populations were exposed to Trypanosoma cruzi or Toxoplasma gondii, obligate intracellular protozoan parasites that cause Chagas' disease and toxoplasmosis, respectively, in humans. The ability of the two parasites to infect HeLa cells increased as the HeLa cells proceeded from the G1 phase to the S phase of their growth cycle and decreased as the cells entered G2-M. Characterization of the S-phase cell surface components responsible for this phenomenon could be beneficial in the development of vaccines against these parasitic diseases.
Authors:
J A Dvorak; M S Crane
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  214     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-01-09     Completed Date:  1982-01-09     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1034-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle*
Hela Cells / physiology
Humans
Kinetics
Toxoplasma / pathogenicity,  physiology*
Trypanosoma cruzi / pathogenicity,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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