Document Detail


Vertebral osteomyelitis due to Candida species: case report and literature review.
MedLine Citation:
PMID:  11462190     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Candida species uncommonly cause vertebral osteomyelitis. We present a case of lumbar vertebral osteomyelitis caused by Candida albicans and review 59 cases of candidal vertebral osteomyelitis reported in the literature. The mean age was 50 years, and the lower thoracic or lumbar spine was involved in 95% of patients. Eighty-three percent of patients had back pain for >1 month, 32% presented with fever, and 19% had neurological deficits. The erythrocyte sedimentation rate was elevated in 87% of patients, and blood culture yielded Candida species for 51%. C. albicans was responsible for 62% of cases, Candida tropicalis for 19%, and Candida glabrata for 14%. Risk factors for candidal vertebral osteomyelitis were the presence of a central venous catheter, antibiotic use, immunosuppression, and injection drug use. Medical and surgical therapies were both used, and amphotericin B was the primary antifungal agent. Prognosis was good, with an overall clinical cure rate of 85%.
Authors:
D J Miller; G C Mejicano
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2001-07-20
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  33     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-19     Completed Date:  2001-10-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  523-30     Citation Subset:  IM    
Affiliation:
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Ave., Madison, WI 53706, USA. djm@medicine.wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Candida / classification*,  isolation & purification
Candida albicans / classification,  isolation & purification
Candidiasis / microbiology*
Female
Humans
Lumbar Vertebrae
Male
Osteomyelitis / microbiology*
Spondylitis / microbiology*
Thoracic Vertebrae

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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