| Vertebral blood perfusion reduction associated with vertebral bone mineral density reduction: a dynamic contrast-enhanced MRI study in a rat orchiectomy model. | |
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MedLine Citation:
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PMID: 19025958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the relationship between vertebral blood perfusion and vertebral bone mineral density (BMD) in a rat orchiectomy (ORX) model. MATERIALS AND METHODS: Nine 6-month-old male Wistar-Kyoto rats were used. Computed tomography (CT) bone densitometry and dynamic MRI were performed at baseline and four weeks post-ORX. MRI was performed on a 1.5 T clinical MR scanner with a small surface coil placed under the rat lumbar spine region. A sagittal midsection of the lumbar spine was prescribed. Dynamic MRI was performed after a bolus injection of gadolinium-tetraazacyclododecane tetraacetic acid (Gd-DOTA) (0.3 mmol/kg) administered through a tail vein cannula. At a temporal resolution of 0.6 seconds, 800 images were acquired. Regions-of-interest were drawn comprising the medullary component of lumbar vertebrae L3-L6. Maximum enhancement was analyzed. RESULTS: Satisfactory CT and MRI data for analysis was obtained in all animals. Vertebral BMD decreased by 16.6% at four weeks post-ORX (1.134 +/- 0.035 vs. 0.946 +/- 0.027 g/cm(3), P = 0.008). MRI maximum enhancement decreased by 17% at four weeks post-ORX (151.5 +/- 12.0% vs. 125.8 +/- 9.9%, P = 0.015). CONCLUSION: Vertebral blood perfusion reduction is associated with vertebral BMD reduction in a male rat osteoporosis model. Perfusion MRI provides a new investigative technique for osteoporosis experimental research. |
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Authors:
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Yi-Xiang J Wang; Ya-Feng Zhang; James F Griffith; Hua Zhou; David K W Yeung; Timothy C Kwok; Ling Qin; Anil T Ahuja |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 28 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-01 Completed Date: 2009-02-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1515-8 Citation Subset: IM |
Copyright Information:
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(c) 2008 Wiley-Liss, Inc. |
Affiliation:
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Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People's Republic of China. yixiang_wang@cuhk.edu.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Density* Contrast Media Heterocyclic Compounds Lumbar Vertebrae / blood supply* Magnetic Resonance Imaging / methods* Male Orchiectomy Organometallic Compounds Rats Rats, Wistar Statistics, Nonparametric Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 92923-44-9/gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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