Document Detail


Vertebral aspergillosis. A case report and review of the literature.
MedLine Citation:
PMID:  8237349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of Aspergillus osteomyelitis of the spine is presented and the world literature is reviewed, for a total of 32 cases. Aspergillus osteomyelitis is rare, but the spine is most frequently affected. It can be induced hematogenously, by contiguity or by direct inoculation. Up to now medical treatment has been based on amphotericin B, but its toxicity is problematic. Itraconazole and fluconazole do not have this shortcoming. Additional surgery has been advocated in the past. In the present series combined medical-surgical treatment (20 cases) led to a higher survival rate (70%) than medical treatment (12 cases: 58%), but neurological recovery was much more frequent in the second group (40% versus 13%).
Authors:
K D'Hoore; M Hoogmartens
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta orthopaedica Belgica     Volume:  59     ISSN:  0001-6462     ISO Abbreviation:  Acta Orthop Belg     Publication Date:  1993  
Date Detail:
Created Date:  1993-12-01     Completed Date:  1993-12-01     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  2985165R     Medline TA:  Acta Orthop Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  306-14     Citation Subset:  IM    
Affiliation:
Department of Orthopaedic Surgery, University Hospital Pellenberg, Katholieke Universiteit Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Aspergillosis / drug therapy,  microbiology*
Aspergillus fumigatus / isolation & purification*
Discitis / microbiology*
Female
Humans
Itraconazole / therapeutic use
Lumbar Vertebrae*
Middle Aged
Osteomyelitis / microbiology*
Chemical
Reg. No./Substance:
84625-61-6/Itraconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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