| Versicolorin A hemiacetal, hydroxydihydrosterigmatocystin, and aflatoxin G2 alpha reductase activity in extracts from Aspergillus parasiticus. | |
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MedLine Citation:
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PMID: 2233978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Versicolorin A hemiacetal was converted to versicolorin C in cell-free systems from Aspergillus parasiticus. The rate of reaction catalyzed by the 35-70% ammonium sulfate fraction was 0.43 nmol min-1 mg-1 with NADPH as cosubstrate and 0.17 nmol min-1 mg-1 with NADH at 25 degrees C at pH 7.4. The product from incubation of 17-hydroxy-16,17-dihydrosterigmatocystin with the 35-70% ammonium sulfate fraction and NADPH was a polar compound which was converted to dihydrosterigmatocystin by 0.4 M HCl. The polar compound is proposed to be the 14,17-hydrated open-chain derivative of dihydrosterigmatocystin. Aflatoxin G2 alpha was also reduced in this system to a polar product tentatively identified as the 13,16-hydrated open-chain derivative of AFG2. The reductase activity may be involved in the formation of reduced intermediates and aflatoxins in cultures of A. parasiticus. |
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Authors:
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J A Anderson; C H Chung; S H Cho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mycopathologia Volume: 111 ISSN: 0301-486X ISO Abbreviation: Mycopathologia Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-12-21 Completed Date: 1990-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7505689 Medline TA: Mycopathologia Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 39-45 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Biochemistry, Texas Tech University, Lubbock 79409-1061. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Oxidoreductases
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metabolism* Anthraquinones / metabolism* Aspergillus / enzymology, metabolism* NAD / metabolism NADP / metabolism Oxidation-Reduction Sterigmatocystin / analogs & derivatives*, metabolism Substrate Specificity |
| Chemical | |
Reg. No./Substance:
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0/Anthraquinones; 10048-13-2/Sterigmatocystin; 109278-36-6/17-hydroxy-16,17-dihydrosterigmatocystin; 53-59-8/NADP; 53-84-9/NAD; 63324-95-8/versicolorin A hemiacetal; EC 1.1.-/Alcohol Oxidoreductases; EC 1.1.1.-/aflatoxin G2a reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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