Document Detail


Versicolorin A hemiacetal, hydroxydihydrosterigmatocystin, and aflatoxin G2 alpha reductase activity in extracts from Aspergillus parasiticus.
MedLine Citation:
PMID:  2233978     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Versicolorin A hemiacetal was converted to versicolorin C in cell-free systems from Aspergillus parasiticus. The rate of reaction catalyzed by the 35-70% ammonium sulfate fraction was 0.43 nmol min-1 mg-1 with NADPH as cosubstrate and 0.17 nmol min-1 mg-1 with NADH at 25 degrees C at pH 7.4. The product from incubation of 17-hydroxy-16,17-dihydrosterigmatocystin with the 35-70% ammonium sulfate fraction and NADPH was a polar compound which was converted to dihydrosterigmatocystin by 0.4 M HCl. The polar compound is proposed to be the 14,17-hydrated open-chain derivative of dihydrosterigmatocystin. Aflatoxin G2 alpha was also reduced in this system to a polar product tentatively identified as the 13,16-hydrated open-chain derivative of AFG2. The reductase activity may be involved in the formation of reduced intermediates and aflatoxins in cultures of A. parasiticus.
Authors:
J A Anderson; C H Chung; S H Cho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mycopathologia     Volume:  111     ISSN:  0301-486X     ISO Abbreviation:  Mycopathologia     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-12-21     Completed Date:  1990-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505689     Medline TA:  Mycopathologia     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock 79409-1061.
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MeSH Terms
Descriptor/Qualifier:
Alcohol Oxidoreductases / metabolism*
Anthraquinones / metabolism*
Aspergillus / enzymology,  metabolism*
NAD / metabolism
NADP / metabolism
Oxidation-Reduction
Sterigmatocystin / analogs & derivatives*,  metabolism
Substrate Specificity
Chemical
Reg. No./Substance:
0/Anthraquinones; 10048-13-2/Sterigmatocystin; 109278-36-6/17-hydroxy-16,17-dihydrosterigmatocystin; 53-59-8/NADP; 53-84-9/NAD; 63324-95-8/versicolorin A hemiacetal; EC 1.1.-/Alcohol Oxidoreductases; EC 1.1.1.-/aflatoxin G2a reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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