Document Detail

Versatility in the acquisition of energy and carbon sources by the Apicomplexa.
MedLine Citation:
PMID:  20586726     Owner:  NLM     Status:  MEDLINE    
Members of the phylum Apicomplexa are motile and rapidly dividing intracellular parasites, able to occupy a large spectrum of niches by infecting diverse hosts and invading various cell types. As obligate intracellular parasites, most apicomplexans only survive for a short period extracellularly, and, during this time, have a high energy demand to power gliding motility and invasion into new host cells. Similarly, these fast-replicating intracellular parasites are critically dependent on host-cell nutrients as energy and carbon sources, noticeably for the extensive membrane biogenesis imposed during growth and division. To access host-cell metabolites, the apicomplexans Toxoplasma gondii and Plasmodium falciparum have evolved strategies that exquisitely reflect adaptation to their respective niches. In the present review, we summarize and compare some recent findings regarding the energetic metabolism and carbon sources used by these two genetically tractable apicomplexans during host-cell invasion and intracellular growth and replication.
Valerie Polonais; Dominique Soldati-Favre
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-23
Journal Detail:
Title:  Biology of the cell / under the auspices of the European Cell Biology Organization     Volume:  102     ISSN:  1768-322X     ISO Abbreviation:  Biol. Cell     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-09-27     Revised Date:  2011-01-21    
Medline Journal Info:
Nlm Unique ID:  8108529     Medline TA:  Biol Cell     Country:  England    
Other Details:
Languages:  eng     Pagination:  435-45     Citation Subset:  IM    
Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
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MeSH Terms
Carbon / metabolism
Energy Metabolism
Erythrocytes / parasitology
Host-Parasite Interactions
Lipids / biosynthesis
Metabolic Networks and Pathways
Plasmodium falciparum / metabolism*
Protozoan Proteins / metabolism
Toxoplasma / metabolism*
Reg. No./Substance:
0/Lipids; 0/Protozoan Proteins; 7440-44-0/Carbon

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