Document Detail

Versatile Enantioselective [3+2] Cyclization between Imines and Allenoates Catalyzed by Dipeptide-Based Phosphines.
MedLine Citation:
PMID:  22162303     Owner:  NLM     Status:  Publisher    
A fast one: The title reaction proceeds in the presence of 5 mol % of the catalyst 1, and is complete within an hour. The 2-alkyl- and 2-aryl-substituted 3-pyrroline products are obtained in good yield and with high enantioselectivity. The application of the method to the concise formal synthesis of (+)-trachelanthamidine is also demonstrated. Boc=tert-butoxycarbonyl, M.S.=molecular sieves, TBDPS=tert-butyldiphenylsilyl.
Xiaoyu Han; Fangrui Zhong; Youqing Wang; Yixin Lu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-7
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  -     ISSN:  1521-3773     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore).
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