Document Detail

Verruciform xanthoma in the setting of cutaneous trauma and chronic inflammation: report of a patient and a brief review of the literature.
MedLine Citation:
PMID:  19958440     Owner:  NLM     Status:  MEDLINE    
We report a rare case of multiple, co-exisitng verruciform xanthomas (VXs) of the anogenital region in the setting of cutaneous trauma. VX is a rare benign mucocutaneous neoplasm that typically presents as a solitary lesion with a predilection for the oral cavity, although extra-oral lesions have been reported involving the vulva, scrotum, penis, anal region and extremities. The etiology and pathogenesis of VX have yet to be determined; however, recent literature has reported that multifocal cutaneous VX are frequently associated with pre-existing inflammatory processes. A significant number of VXs of the skin have been found to co-exist with cutaneous disorders including graft vs. host disease, discoid lupus erythematosus, pemphigus vulgaris, and recessive dystrophic epidermolysis bullosa. Therefore, we speculate severe cutaneous trauma and chronic inflammation may induce epithelial keratinocytes to respond aberrantly leading to epidermal hyperplasia and foamy cell formation characterizing the VX lesion.
Lara Cumberland; Ali Dana; Brooke Resh; James Fitzpatrick; Gary Goldenberg
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-12-02
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  37     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-10-25     Revised Date:  2012-03-22    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  895-900     Citation Subset:  IM    
Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA.
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MeSH Terms
Anus Diseases / pathology*
Foam Cells / pathology
Inflammation / pathology
Xanthomatosis / pathology*
Comment In:
J Cutan Pathol. 2012 Mar;39(3):391-4   [PMID:  21362016 ]

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