Document Detail


Vernakalant in an experimental model of pacing-induced heart failure: Lack of proarrhythmia despite prolongation of repolarization.
MedLine Citation:
PMID:  25084217     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The present ESC guidelines on atrial fibrillation have introduced vernakalant (VER) for pharmacological cardioversion of atrial fibrillation. Therefore, the aim of the present study was to investigate possible proarrhythmic effects of vernakalant in an experimental model of heart failure (HF).
METHODS AND RESULTS: In twelve female rabbits, HF was induced by 4 weeks of rapid ventricular pacing. Twelve rabbits were sham-operated. Isolated hearts demonstrated a significant prolongation of myocardial repolarization after induction of heart failure. Vernakalant caused a concentration-dependent (10 and 30μM) increase of action potential duration (APD90) and QT-interval without affecting spatial and temporal dispersion of repolarization. The increase in APD90 was accompanied by a greater increase in refractory period resulting in a significant increase in post-repolarization refractoriness. In control conditions, programmed ventricular stimulation and burst pacing led to ventricular fibrillation (VF) in 2 of 12 sham- (4 episodes) and in 3 of 12 failing (24 episodes) hearts. In the presence of 30μM vernakalant, VF was no longer inducible in both groups (0 episodes). In the presence of low [K(+)], neither sham nor failing vernakalant-treated hearts developed early afterdepolarizations or ventricular tachyarrhythmias.
CONCLUSION: In the present study, application of vernakalant led to a significant prolongation of myocardial repolarization and increased PRR but did not induce EAD and therefore did not cause proarrhythmia in failing hearts.
Authors:
Gerrit Frommeyer; Jochen Schulze Grotthoff; Christina Fischer; Harilaos Bogossian; Florian Reinke; Simon Kochhäuser; Dirk G Dechering; Michael Fehr; Peter Milberg; Lars Eckardt
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-29
Journal Detail:
Title:  Journal of cardiac failure     Volume:  -     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-8-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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