| Verification of global cerebral ischaemia using scintigraphy. | |
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MedLine Citation:
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PMID: 6152315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The induction of global cerebral ischaemia in laboratory animals is difficult to accomplish and has been even more difficult to verify. Most reported verification methods suffer from lack of sensitivity or from being traumatic and highly invasive. We describe a non-traumatic global cerebral ischaemia verification technique which is quantitative, simple, and highly sensitive. Radioactive technetium-99m pertechnetate is injected intravenously during the ischaemic phase of an experiment and the appearance of radioactivity within the animal's head is quantitated using a gamma camera and nuclear medicine computer. Radioactivity levels below the visual perception threshold are readily measured, thus providing a high degree of confidence in assessing the partial or total nature of cerebral ischaemia. |
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Authors:
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A R Benedetto; M L Lecklitner; A S Hernandez; M S Albin; L Bunegin; M L Nusynowitz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurological research Volume: 6 ISSN: 0161-6412 ISO Abbreviation: Neurol. Res. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-05-09 Completed Date: 1985-05-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 199-202 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / radionuclide imaging* Cerebrovascular Circulation Computers Disease Models, Animal Rats Scintillation Counting / instrumentation Sodium Pertechnetate Tc 99m / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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RR 05654/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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23288-60-0/Sodium Pertechnetate Tc 99m |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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