Document Detail


Verification of the biphasic response in intraocular pressure during treatment of glaucoma patients with 3% guanethidine and 0.5% adrenaline.
MedLine Citation:
PMID:  7249915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a long-term study with 3% guanethidine and 0.5% adrenaline in on eye drop (GA) the combined results of patients with primary open angle glaucoma (POAG) and glaucoma suspects showed a biphasic response in intraocular pressure (IOP). The hypertensive phase peaked 3 hrs after administration (at noon) and reached a maximum of 3.5 mm Hg (p less than 0.005) above the hypotensive phase. It is reported in the literature that during office hours untreated glaucoma patients show a peak near noon, suggesting that the initial increase in IOP may be the normal IOP pattern. When the data of untreated patients with POAG and glaucoma suspects were separated, an increase in IOP around noon in the first group and a decrease around noon in the glaucoma suspects was found. However, during GA-treatment both groups showed a hypertensive response at noon (3 hrs). In addition, the highest IOP's in day curves were timed during and without GA. It was shown that during GA there was a shift in the incidence of the highest IOP's towards noon (from 8.3% to 73.2% for patients with suspected glaucoma and from 32% to 63.6% for those with POAG). It was therefore concluded that GA induces a characteristic biphasic IOP pattern in patients with POAG as well as in glaucoma suspects. Also, glaucoma suspects may have higher peak pressures more frequently than POAG patients. Furthermore, the study showed that during office hours untreated glaucoma suspects have day curves with higher pressures in the morning while patients with POAG have higher pressures near noon.
Authors:
P F Hoyng
Related Documents :
9264305 - Brimonidine: a new alpha2-adrenoreceptor agonist for glaucoma treatment.
2964995 - The effect of nebulized bronchodilator therapy on intraocular pressures in patients wit...
720955 - Increased level of factor viii complex in severe arterial hypertension.
7845645 - Influence of topical anesthesia on tonometric values of intraocular pressure.
17053265 - Hemodynamic changes during discontinuation of mechanical ventilation in medical intensi...
7919625 - High-output heart failure as a cause of pulmonary hypertension.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Documenta ophthalmologica. Advances in ophthalmology     Volume:  51     ISSN:  0012-4486     ISO Abbreviation:  Doc Ophthalmol     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370667     Medline TA:  Doc Ophthalmol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  161-73     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Drug Combinations
Epinephrine / pharmacology,  therapeutic use*
Glaucoma / drug therapy*
Guanethidine / pharmacology,  therapeutic use*
Humans
Intraocular Pressure / drug effects*
Periodicity
Chemical
Reg. No./Substance:
0/Drug Combinations; 51-43-4/Epinephrine; 55-65-2/Guanethidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Alternating strabismus--clinical study--treatment
Next Document:  Guanethidine - adrenaline eye drops in glaucoma simplex. Pupil behaviour and response of intraocular...