Document Detail


Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease.
MedLine Citation:
PMID:  23154124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Cognitive impairment, including impairment of episodic memory, is frequently found in newly diagnosed Parkinson's disease (PD). In this longitudinal observational study we investigated whether performance in memory encoding, retention, recognition and free recall is associated with reduced hippocampal radial distance.
METHODS: We analysed baseline T1-weighted brain MRI data from 114 PD subjects without cognitive impairment, 29 PD subjects with mild cognitive impairment and 99 normal controls from the ParkWest study. Age- and education-predicted scores for the California Verbal Learning Test 2 (CVLT-2) and tests of executive function were regressed against hippocampal radial distance while adjusting for imaging centre.
RESULTS: There was no association between encoding or performance on executive tests and hippocampal atrophy in the PD group. In the full PD sample we found bilaterally significant associations between lower delayed free recall scores and hippocampal atrophy in the CA1, CA3 and subiculum area (left, p=0.0013; right, p=0.0082). CVLT-2 short delay free recall scores were associated with bilateral hippocampal CA1 and subicular atrophy in the full PD sample (left, p=0.013; right, p=0.047). CVLT-2 recognition scores showed a significant association with right-sided subicular and CA1 atrophy in the full PD sample (p=0.043).
CONCLUSIONS: At the time of PD diagnosis, subjects' verbal memory performance in recall and recognition are associated with atrophy of the hippocampus, while encoding is not associated with hippocampal radial distance. We postulate that impaired recall and recognition might reflect deficient memory consolidation at least partly due to structural hippocampal changes.
Authors:
Mona K Beyer; Kolbjorn S Bronnick; Kristy S Hwang; Niels Bergsland; Ole Bjorn Tysnes; Jan Petter Larsen; Paul M Thompson; Johanne H Somme; Liana G Apostolova
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-15
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  84     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-02-22     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  23-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Atrophy / psychology
Female
Hippocampus / pathology*
Humans
Longitudinal Studies
Magnetic Resonance Imaging / methods,  psychology
Male
Memory*
Mild Cognitive Impairment / complications,  pathology*
Neuroimaging / methods,  psychology*
Neuropsychological Tests / statistics & numerical data
Parkinson Disease / complications,  pathology*,  psychology*
Psychomotor Performance
Grant Support
ID/Acronym/Agency:
AG16570/AG/NIA NIH HHS; EB01651/EB/NIBIB NIH HHS; LM05639/LM/NLM NIH HHS; P50 AG016570/AG/NIA NIH HHS; RR019771/RR/NCRR NIH HHS
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