Document Detail


Verapamil therapy: a new approach to pharmacologic treatment of hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  6995039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hemodynamic and clinical effects of verapamil administration were examined in patients with hypertrophic cardiomyopathy. Infusion of 0.021 mg/kg/min of verapamil decreased the basal left ventricular outflow tract gradient from 94 +/- 14 to 49 +/- 14 mm Hg, while cardiac index increased from 2.5 +/- 0.2 to 2.8 +/- 0.2 L/min/sq m. Orally administered, 80 or 120 mg four times daily (QID), increased exercise capacity relative to placebo by 26% (1.6 +/- 0.5 minute; p less than 0.005) and propranolol, 40 or 80 mg QID, increased it by 21 +/- 8% (1.3 +/- 0.5 minute, p less than 0.025). Nine patients considered their symptomatic status "best" while receiving verapamil, seven while receiving placebo, and only three while receiving propranolol. Seventy-three patients have been discharged from the hospital receiving long-term verapamil therapy, and 49 have reported continuing symptomatic benefit with many showing improved exercise capacity up to two years later. Thus, verapamil can improve exercise capacity and symptomatic status in certain patients with hypertrophic cardiomyopathy, thereby providing physicians with a new therapeutic agent for the treatment of this disorder.
Authors:
D R Rosing; K M Kent; B J Maron; J Condit; S E Epstein
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Chest     Volume:  78     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-47     Citation Subset:  AIM; IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aortic Stenosis, Subvalvular / drug therapy*
Blood Pressure
Cardiac Output
Cardiomyopathy, Hypertrophic / drug therapy*,  physiopathology
Clinical Trials as Topic
Double-Blind Method
Female
Heart Rate
Humans
Male
Middle Aged
Physical Exertion
Placebos
Verapamil / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Placebos; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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