| Verapamil therapy in variant angina pectoris refractory to nitrates. | |
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MedLine Citation:
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PMID: 6791484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Conventional therapy including nitrates, beta blockers, and surgical bypass has proved to be generally unsatisfactory in patients with variant angina of suspected vasospastic etiology. Recent evidence regarding the role of calcium in the pathogenesis of vascular smooth muscle spasm prompted an open study of the clinical effects of verapamil in seven patients with recurrent rest angina refractory to nitrates. The patients studied met strict clinical ECG and angiographic criteria for vasospastic angina. All patients had rapid (within 24 hours) and complete (without recurrence of symptoms) chronic response to oral verapamil therapy. The pharmacology of verapamil relating to the pathogenesis of vasospastic angina is delineated and guidelines for the clinical application of the agent are presented. |
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Authors:
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W R Freeman; T Peter; W J Mandel |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American heart journal Volume: 102 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1981 Sep |
Date Detail:
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Created Date: 1981-10-29 Completed Date: 1981-10-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 358-62 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angina Pectoris / drug therapy* Angina Pectoris, Variant / drug therapy* Electrocardiography Ergonovine / diagnostic use Female Humans Isosorbide Dinitrate / adverse effects Male Middle Aged Nitrates / adverse effects* Nitroglycerin / adverse effects Verapamil / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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HL 17651/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nitrates; 52-53-9/Verapamil; 55-63-0/Nitroglycerin; 60-79-7/Ergonovine; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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