Document Detail


Verapamil-sensitive left ventricular tachycardia in patients with coronary artery disease: clinical and electrophysiologic features consistent with triggered activity.
MedLine Citation:
PMID:  11720598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This is a retrospective review of three male patients with verapamil-sensitive left ventricular tachycardia, severe coronary artery disease, and past myocardial infarction. Each patient had severe left ventricular dysfunction (mean ejection fraction 34%). Each tachycardia had a right bundle branch block/left axis deviation morphology, which was sustained with isoproterenol. One patient had incessant tachycardia 3 days after coronary bypass surgery. Electrophysiology and clinical parameters were suggestive of triggered activity rather than reentry. Each tachycardia was terminated with verapamil but failed with adenosine, beta blockers, and class I/III antiarrhythmics. Prior cases of verapamil-sensitive ventricular tachycardia have been seen in patients without organic heart disease, and the putative mechanism appears to be reentry. These patients with ischemic coronary artery disease may exhibit a mechanism of triggered activity in the Purkinje system region, which is responsive to calcium channel blockade. Successful radiofrequency ablation was guided by Purkinje potentials.
Authors:
C Sorbera; M Cohen; V Kuznetsov; S Dhakham
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Heart disease (Hagerstown, Md.)     Volume:  1     ISSN:  1521-737X     ISO Abbreviation:  Heart Dis     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  2001-11-26     Completed Date:  2002-01-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100887299     Medline TA:  Heart Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2-7     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Arrhythmia Agents / therapeutic use*
Bundle-Branch Block / physiopathology,  surgery,  therapy
Catheter Ablation
Coronary Disease / complications*
Humans
Male
Retrospective Studies
Tachycardia, Ventricular / etiology,  physiopathology,  therapy*
Verapamil / therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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