Document Detail


Verapamil-resistant contractile activation of isolated coronary artery produced by hyperosmolar solutions.
MedLine Citation:
PMID:  3923958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pig coronary strips were exposed to sucrose-, mannitol- or NaCl-hyperosmolar Tyrode solution and to a solution containing varying concentrations of calcium or potassium ions. In the hyperosmolar solutions obtained by addition of sucrose, mannitol and NaCl to 540, 556 and 308 mM, respectively, the resting tension was increased, while isometric tension development upon electrical stimulation was decreased. Increase in the Ca2+ and K+ concentrations augmented the phasic contraction upon electrical stimulation and produced a rise in the resting tension. The contractions produced by hyperosmolarity, high Ca2+ and K+ were susceptible to metabolic blockades, hypoxia, low temperature and glucose deprivation. The increase in the resting tension produced by hyperosmolarity was resistant to verapamil and persisted in Ca2+-free hyperosmolar solution, while the effects of additional Ca2+ and K+ on the phasic and tonic contractions were inhibited by verapamil. The results suggest that tension development in coronary artery produced by hyperosmolarity does not require verapamil-sensitive entry of Ca2+, but Ca2+ presumably supplied from intracellular stores.
Authors:
K Nakayama
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  273     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-07-12     Completed Date:  1985-07-12     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  117-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / physiology
Coronary Vessels / drug effects*,  metabolism
Dantrolene / pharmacology
Drug Resistance
Hypertonic Solutions / pharmacology*
Mannitol / pharmacology
Potassium / pharmacology
Procaine / pharmacology
Saline Solution, Hypertonic / pharmacology
Strophanthins / pharmacology
Sucrose / pharmacology
Swine
Vasoconstriction / drug effects*
Verapamil / pharmacology*
Chemical
Reg. No./Substance:
0/Hypertonic Solutions; 0/Saline Solution, Hypertonic; 0/Strophanthins; 11005-63-3/strophanthin K; 52-53-9/Verapamil; 57-50-1/Sucrose; 59-46-1/Procaine; 69-65-8/Mannitol; 7261-97-4/Dantrolene; 7440-09-7/Potassium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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