Document Detail

Verapamil prevents the acute hypertensive response to intracerebroventricular cadmium in conscious normotensive rats.
MedLine Citation:
PMID:  8466705     Owner:  NLM     Status:  MEDLINE    
Cadmium, a trace element from natural and industrial sources, may contribute to the pathogenesis of arterial hypertension. We evaluated the effect induced by acute intracerebroventricular (icv) administration of cadmium on mean blood pressure of normotensive conscious rats. Intracerebroventricular cadmium (1 to 10 micrograms) produced a dose-dependent, sustained increase in mean blood pressure. The hypertensive response to icv cadmium was significantly (P < .01) prevented by icv pretreatment with verapamil (10 to 100 micrograms). A preventive effect was exerted also by icv nifedipine (100 micrograms); however, this result was attributable, at least in part, to the antihypertensive action of the vehicle, polyethylene glycol. The hypertensive response to icv cadmium was blunted by icv administration of 10 ng clonidine, 10 micrograms vasopressin antagonist, or 10 micrograms bradykinin antagonist (P < .05), but it was not altered by icv enalaprilat (100 micrograms). These results indicate that brain calcium channels play a role in the hypertensive action induced by icv cadmium. Accumulation of cadmium in the brain caused by prolonged exposure to this heavy metal might lead to chronic arterial hypertension.
P Madeddu; M P Demontis; M V Varoni; M C Fattaccio; A Palmieri; V Anania
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  6     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-12     Completed Date:  1993-05-12     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
Clinica Medica, University of Sassari, Italy.
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MeSH Terms
Acute Disease
Blood Pressure / drug effects
Brain / physiology*
Cadmium* / administration & dosage,  pharmacology
Dose-Response Relationship, Drug
Hypertension / chemically induced*,  prevention & control*
Injections, Intraventricular
Rats, Wistar
Reference Values
Verapamil / pharmacology*
Reg. No./Substance:
52-53-9/Verapamil; 7440-43-9/Cadmium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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